小鼠IL-23ELISA试剂盒描述:
Interleukin-23 subunit α (IL-23) is a protein that in humans is encoded by the IL23A gene. IL-23 is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 α subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis, and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. The International Radiation Hybrid Mapping Consortium mapped the p19 gene to chromosome 12 (stSG47812). ScienCell’s mouse IL-23 ELISA kit is based on standard sandwich enzyme-linked immune-sorbent assay technology. Mouse IL-23-specific polyclonal antibodies are pre-coated onto 8 x 12 divisible strips. The mouse-specific detection monoclonal antibodies (clone No. 35928.11) are biotinylated. The test samples and biotinylated detection antibodies are subsequently added to the wells and then washed with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex is added and unbound conjugates are washed away with PBS or TBS buffer. HRP substrate TMB is used to visualize HRP enzymatic reaction. TMB is catalyzed by HRP to produce a blue color product that changes to yellow after adding acidic stop solution. The intensity of yellow is proportional to the amount of mouse IL-23 in the sample that is captured on the strips.
产品使用说明:仅供科研研究使用
货号 |
EK0866 |
产地 |
美国 |
缩写 |
mIL23-ELISA |
规格 |
96 tests |
用途 |
科研 |
保存 |
频繁使用存储在4°C,很少使用存储在-20°C |
运输 |
胶冰 |
参考文献 |
1. Oppmann B, Lesley R, Blom B, Timans JC, Xu
Y, Hunte B, VegaF, Yu N, Wang J, Singh K, ZoninF, Vaisberg E, Churakova T,
Liu M, Gorman D, Wagner J, Zurawski S, Liu Y, Abrams JS, Moore KW, Rennick D,
de Waal-Malefyt R, Hannum C, Bazan JF, Kastelein RA (Jan 2001). "Novel
p19 protein engages IL-12p40 toForm a cytokine, IL-23, with biological
activities similar as well as distinctFrom IL-12". Immunity 13 (5):
715-25. |
2. "Entrez Gene: IL23A interleukin 23, alpha subunit p19".
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