产品名称	Caov-3人卵巢腺癌细胞
货号	ZQ0484
产品介绍	Caov-3细胞系是一种源自人类卵巢腺癌的癌细胞系，它在1976年首次从一位54岁白人女性的卵巢腺癌组织中被分离并建立。这些细胞具有类似于上皮细胞的形态，并在实验室培养条件下能够形成密集的细胞菌落，模拟原发性卵巢癌的细胞行为。在遗传学上，Caov-3细胞展示了p53基因的一个无义突变，以及PIK3CA基因的多个拷贝，后者是一个与卵巢癌相关的癌基因。这些细胞表现出明显的致瘤性，即它们能够在宿主体内形成肿瘤，并且对几种常用的化疗药物，包括长春碱、顺铂和阿霉素表现出敏感性。尽管Caov-3细胞不能在软琼脂中生长，它们仍然能够在免疫功能受损的小鼠体内引起癌症，这使得它们成为3D细胞培养实验的理想选择。作为一个研究工具，Caov-3细胞系对于理解卵巢癌的生物学基础和发展新的治疗策略至关重要。通过使用这些细胞进行研究，科学家们可以探索疾病的复杂机制，并测试新的治疗方法。 注意事项：该细胞贴壁较慢，请于贴壁48小时后再进行观察或后续操作。 caov-3细胞胞体上有黑色颗粒，并且分泌少量黑色颗粒是正常现象。
种属	人
性别/年龄	女/54岁
组织	卵巢
疾病	腺癌
细胞类型	肿瘤细胞
形态学	上皮的
生长方式	贴壁
倍增时间	大约44~78小时
培养基和添加剂	DMEM高糖（中乔新舟 货号：ZQ-100）+10%胎牛血清（中乔新舟货号：ZQ0500）+1%双抗（中乔新舟货号：CSP006）+1% Sodium Pyruvate 100 mM Solution（中乔新舟货号：CSP003）
推荐完全培养基货号	ZM0484
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 10,13 D13S317: 12 D16S539: 9 D5S818: 12 D7S820: 10 THO1: 7 TPOX: 8,10 vWA: 16,18
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-75
供应限制	仅供科研使用

货号	ZQ0484
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition
DOI： 10.1007/s00418-020-01877-7
发表时间： 2020-05-07
期刊： HISTOCHEMISTRY AND CELL BIOLOGY
影响因子： 4.304
货号： ZQ0484
产品名称： CAOV-3 cells

原文链接： https://link.springer.com/content/pdf/10.1007/s00418-020-01877-7.pdf

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