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U-937人组织细胞淋巴瘤细胞(STR鉴定)
英文名:U-937
货号:ZQ0087
价格:¥1600.00
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U-937人组织细胞淋巴瘤细胞(STR鉴定)

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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

U-937人组织细胞淋巴瘤细胞

货号

ZQ0087

产品介绍

U-937是一种人组织细胞淋巴瘤细胞系,最初由Sundstrom和Nilsson在1974年从一位37岁白人男性患者细胞淋巴瘤病人的胸腔积液中分离得到。这种细胞系具有单核细胞形态,能在悬浮状态下生长,并且可以通过特定的诱导剂如人混合淋巴细胞培养上清、佛波脂、维生素D3、γ干扰素、肿瘤坏死因子和维甲酸等诱导终末单核细胞分化。该细胞免疫球蛋白产物和EB病毒表达为阴性。该细胞表达federation of american scientists 美国科学家联合会抗原且对TNF和抗-Fas抗体敏感。
U-937细胞系在免疫学、肿瘤学、细胞生物学和药理学研究中有着广泛的应用。例如:免疫学研究中通常用于以下类型的实验:细胞分化研究、细胞信号传导、免疫调节、肿瘤免疫、细胞吞噬功能、细胞因子和趋化因子的研究、基因功能研究、药物筛选和毒性测试、炎症研究、巨噬细胞极化等。这些实验有助于理解单核细胞和巨噬细胞的生物学特性,以及它们在疾病状态下的作用机制。
该细胞免疫球蛋白产物和EB病毒表达为阴性。 该细胞表达Fas抗原且对TNF和抗-Fas抗体敏感。也可以作为基因转染的宿主细胞。

种属

性别/年龄

男/37岁

组织

胸膜/胸腔积液,淋巴细胞,髓样

疾病

组织细胞淋巴瘤

细胞类型

肿瘤细胞 

形态学

单核细胞

生长方式

悬浮

倍增时间

大约30~100小时 

培养基和添加剂

RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(中乔新舟   货号:CSP006

推荐完全培养基货号

ZM0087

生物安全等级

BSL-1

STR位点信息

Amelogenin: X

CSF1PO: 12
D13S317: 10,12
D16S539: 12
D5S818: 12
D7S820: 9,11
TH01: 6,9.3
TPOX: 8,11
vWA: 14,15
D3S1358: 16
D21S11: 27,29
D18S51: 13,14
Penta_E: 13
Penta_D: 12,13
D8S1179: 12,13
FGA: 22,25
D19S433: 14,16
D2S1338: 17,20

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

*** 

基因表达

*** 

保藏机构

ATCC; CRL-1593 ATCC; CRL-1593.2 DSMZ; ACC-5 ECACC; 85011440

供应限制

仅供科研使用

货号

ZQ0087

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


1、论文标题: MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells
DOI: 10.1016/j.lfs.2019.117228
发表时间: 2019-12-24
期刊: LIFE SCIENCES
影响因子: 3.448
货号: ZQ0087
产品名称: U937 cells

原文链接: https://www.sciencedirect.com/science/article/pii/S0024320519311567


2、PubMed=16311011; DOI=10.1016/j.tiv.2005.10.012

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Toxicol. In Vitro 20:767-773(2006)


3、PubMed=16337770; DOI=10.1016/j.tiv.2005.10.014
Sakaguchi H., Ashikaga T., Miyazawa M., Yoshida Y., Ito Y., Yoneyama K., Hirota M., Itagaki H., Toyoda H., Suzuki H.
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.
Toxicol. In Vitro 20:774-784(2006)


4、PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)


5、PubMed=20801507; DOI=10.1016/j.leukres.2010.07.040
Minafra L., Di Cara G., Albanese N.N., Cancemi P.
Proteomic differentiation pattern in the U937 cell line.
Leuk. Res. 35:226-236(2011)


6、PubMed=21269460; DOI=10.1186/1752-0509-5-17
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.
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BMC Syst. Biol. 5:17.1-17.13(2011)


7、PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)


8、DOI=10.1016/j.actaastro.2013.06.007
Paulsen K., Tauber S., Golz N., Simmet D.M., Engeli S., Birlem M., Dumrese C., Karer A., Hunziker S., Biskup J., Konopasek S., Suh D., Breuer-Hurlimann E., Signer C., Wang A., Sang C., Grote K.-H., Zhuang F.-Y., Ullrich O.
Severe disruption of the cytoskeleton and immunologically relevant surface molecules in a human macrophageal cell line in microgravity -- results of an in vitro experiment on board of the Shenzhou-8 space mission.
Acta Astronaut. 94:277-292(2013)


9、PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)


10、PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)


11、PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)


12、PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14
Chanput W., Peters V., Wichers H.J.
THP-1 and U937 cells.
(In) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx K., Cotter P., Lopez-Exposito I., Kleiveland C., Lea T., Mackie A., Requena T., Swiatecka D., Wichers H. (eds.); pp.147-159; Springer; Cham (2015)


13、PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)


14、PubMed=30629668; DOI=10.1371/journal.pone.0210404
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)


15、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)


16、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)


17、PubMed=31160637; DOI=10.1038/s41598-019-44491-x
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)


18、PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)


19、PubMed=33317567; DOI=10.1186/s13039-020-00517-y
MacKinnon R.N., Peverall J., Campbell L.J., Wall M.
Detailed molecular cytogenetic characterisation of the myeloid cell line U937 reveals the fate of homologous chromosomes and shows that centromere capture is a feature of genome instability.
Mol. Cytogenet. 13:50.1-50.14(2020)


20、PubMed=34707142; DOI=10.1038/s41598-021-00623-w
Maher M., Diesch J., Le Pannerer M.-M., Cabezon M., Mallo M., Vergara S., Mendez Lopez A., Mesa Tudel A., Sole F., Sorigue M., Zamora L., Granada I., Buschbeck M.
Divergent leukaemia subclones as cellular models for testing vulnerabilities associated with gains in chromosomes 7, 8 or 18.
Sci. Rep. 11:21145-21145(2021)


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