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HEC-1-A人子宫内膜腺癌细胞(STR鉴定)
英文名:HEC-1-A
货号:ZQ0342
价格:¥1400.00
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HEC-1-A人子宫内膜腺癌细胞(STR鉴定)

¥1400.00
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HEC-1-A人子宫内膜腺癌细胞专用培养基

¥350.00 ¥600.00

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细胞套餐惊爆价

¥1750 ¥2000.00
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

HEC-1-A人子宫内膜腺癌细胞

货号

ZQ0342

产品介绍

HEC-1-A细胞是一种特征明确的人子宫内膜腺癌细胞系,来源于71岁白人妇女的恶性组织。该细胞及其亚株HEC-1-B是H. Kuramoto及其同事1968年从一位IA期子宫内膜癌患者身上分离得到的,PAF可以诱导其c-fos的表达。广泛用于妇科癌症研究,特别是研究子宫内膜癌。
HEC-1-A细胞在形态学呈上皮样,培养时形成单层多角形细胞。其表现出健壮的贴壁生长模式,这是来自实体瘤的上皮细胞的典型特征。HEC-1-A细胞的形态学特征使其成为研究与癌症进展相关的细胞行为(如粘附、迁移和侵袭)的有价值模型。从基因的角度来看,该细胞有几种与癌症生物学相关的基因畸变,包括p53和PTEN等关键调控基因的突变,这两种基因在子宫内膜癌中都很常见。这些遗传特征有助于研究子宫内膜癌发生的分子基础以及导致肿瘤生长和抵抗治疗的细胞途径。
使用HEC-1-A细胞进行的研究显著提高了我们对子宫内膜癌的理解,特别是在激素影响、基因突变和对化疗药物的反应方面。因此,该细胞系在开发更有效的子宫内膜癌诊断和治疗策略方面继续发挥着重要作用。

种属

性别/年龄

女/71岁

组织

子宫;子宫内膜

疾病

腺癌

细胞类型

肿瘤细胞 

形态学

上皮的

生长方式

贴壁

倍增时间

大约27~31小时

培养基和添加剂

McCOY's 5A(中乔新舟  货号:ZQ-1000+10%FBS(品牌:中乔新舟 货号:ZQ500-A+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM0342

生物安全等级

BSL-1

STR位点信息

Amelogenin: X
CSF1PO: 10,12
D13S317: 11,12
D16S539: 12,13
D5S818: 11,14,15
D7S820: 9,11
TH01: 6,7
TPOX: 8,11
vWA: 18,19
This cell line has historically exhibited instability at D5S818 #14 and D13S317 #12.

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

 ***

基因表达

 ***

保藏机构

ATCC; HTB-112 BCRC; 60552 JCRB; JCRB1117 JCRB; NIHS0388

供应限制

仅供科研使用

货号

ZQ0342

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


论文标题: Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma
DOI: 10.1038/s41419-021-03762-0
发表时间: 2021-05-26
期刊: Cell Death & Disease
影响因子: 8.469
货号: ZQ0342
产品名称: HEC-1A cells
原文链接: https://www.nature.com/articles/s41419-021-03762-0


论文标题: Elevated expression of LPCAT1 predicts a poor prognosis and is correlated with the tumour microenvironment in endometrial cancer
DOI: 10.1186/s12935-021-01965-1
发表时间: 2021-05-20
期刊: Cancer Cell International
影响因子: 5.722
货号: ZQ0342
产品名称: HEC-1A cell

原文链接: https://link.springer.com/article/10.1186/s12935-021-01965-1



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