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HuT 78人T淋巴细胞白血病细胞 (STR鉴定)
英文名:HuT 78
货号:ZQ0383
价格:¥1500.00
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HuT 78人T淋巴细胞白血病细胞 (STR鉴定)

¥1500.00
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HuT 78人T淋巴细胞白血病细胞专用培养基

¥800.00

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细胞套餐惊爆价

¥2300
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

HuT 78人T淋巴细胞白血病细胞

货号

ZQ0383

产品介绍

HuT 78 是一种皮肤 T 淋巴细胞系,源自一名患有塞扎里综合征的 53 岁白人男性患者系,Sézary综合征是皮肤t细胞淋巴瘤(CTCL)的一种白血病变异型。这些细胞的特点是它们成熟的t辅助表型,表达CD4和缺乏CD8表面标记,与它们来自恶性t细胞群一致。HuT-78细胞在t细胞生物学、免疫反应和淋巴瘤的研究中特别重要,为t细胞白血病和淋巴瘤的分子和细胞机制提供了见解。
HuT-78细胞表现出一系列异常核型,包括复杂的染色体重排和非整倍体,这通常与它们的恶性表型相关。这些细胞对有丝分裂刺激有反应,可用于涉及t细胞激活和信号通路的研究。此外,HuT-78细胞对各种化疗药物都很敏感,这使它们成为测试抗癌药物,特别是针对t细胞淋巴瘤的药物的有价值的模型。研究人员还使用HuT-78细胞来研究淋巴瘤细胞与免疫系统之间的相互作用,从而更好地了解免疫逃避机制。
这种细胞系是悬浮培养的,需要特定的条件来维持活力和生长。HuT-78细胞在促进对CTCL发病机制的理解和开发针对恶性t细胞的潜在治疗策略方面至关重要。然而,重要的是要注意,该细胞系严格用于研究目的,不适合治疗或体内应用。

意事项: 细胞悬浮聚团生长。细胞增殖速度慢,1:2 传代后需要2天换液一次。

种属

性别/年龄

男/53岁

组织

外周血 

疾病

塞扎里综合征

细胞类型

皮肤淋巴细胞(KRAS)

形态学

淋巴母细胞

生长方式

悬浮

倍增时间

大约26~65小时

培养基和添加剂

IMDM(品牌:中乔新舟  货号:ZQ-900+20%FBS(品牌:中乔新舟  货号:ZQ500-A)+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM0383

生物安全等级

BSL-1

STR位点信息

Amelogenin: X,Y

CSF1PO: 11,12

D13S317: 8,12

D16S539: 11,12

D5S818: 11,12

D7S820: 8,11

TH01: 8,9

TPOX: 8,9

vWA: 14,15

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

 ***

基因表达

 ***

保藏机构

ATCC; TIB-161 ATCC; CRM-TIB-161 ECACC; 88041901

供应限制

仅供科研使用

货号

ZQ0383

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


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