产品名称	K-562人慢性髓原白血病细胞
货号	ZQ0424
产品介绍	连续细胞株K-562由Lozzio从一位临终的53岁女性慢性骨髓性白血病患者的胸水中建立。 细胞被归入高度未分化的粒性白细胞类。 Anderson等对其表面膜性质的研究表明，K-562是一株人类红白血病细胞。 K-562细胞株在自然杀伤分析中广泛作为高敏感的体外受体。 See Pross等将它用于NK细胞的体外详细检测，包括NK细胞活性的数学量化。 K-562母细胞是多能性，造血恶性细胞，它能自发分化成可识别的红血球祖细胞、粒性白细胞、单核细胞等。它是EBNA阴性的。 注意事项： a) 该细胞为悬浮细胞，根据培养经验以及客户的反馈，传代时使用【半换液法】对细胞状态较为有利，因此我库建议您使用【半换液法】进行传代。同时，您在收到细胞后，请不要通过离心的方式收集细胞，可以直接向培养瓶中添加等体积的新鲜培养液，然后将细胞吹打均匀后移入两个新的T25培养瓶中继续培养即可。 b) 该细胞对血清质量较为敏感，建议您使用大品牌优质血清进行培养。 c) 该细胞对细胞密度较为敏感，培养、传代时请注意保持细胞密度在合适的范围。细胞接种密度10万个/mL，维持密度10万-100万个/mL.
种属	人
性别/年龄	女/53岁
组织	骨；骨髓
疾病	慢性粒细胞白血病Cml
细胞类型	肿瘤细胞
形态学	成淋巴细胞
生长方式	悬浮
倍增时间	大约17~47小时
常规培养基和添加剂	IMDM培养基（品牌：中乔新舟 货号：ZQ-900）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）
推荐含血清完全培养基货号	ZM0424
推荐无血清完全培养基货号	SFM0424
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 9,10 D13S317: 8 D16S539: 11,12 D5S818: 11,12 D7S820: 9,11 THO1: 9.3 TPOX: 8,9 vWA: 16
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达
基因表达
保藏机构	ATCC; CCL-243 BCRC; 60007 BCRJ; 0126 CCLV; CCLV-RIE 0439 DSMZ; ACC-10 ECACC; 89121407
供应限制	仅供科研使用

货号	ZQ0424
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Hinokiflavone induces apoptosis, cell cycle arrest and autophagy in chronic myeloid leukemia cells through MAPK/NF-κB signaling pathway
DOI： 10.1186/s12906-022-03580-7
发表时间： 2022-04-06
期刊： BMC Complementary and Alternative Medicine
影响因子： 3.659
货号： ZQ0424
产品名称： K562 cell line
原文链接： https://link.springer.com/article/10.1186/s12906-022-03580-7

论文标题： Engineering NK-92 Cell by Upregulating CXCR2 and IL-2 Via CRISPR-Cas9 Improves Its Antitumor Effects as Cellular Immunotherapy for Human Colon Cancer
DOI： 10.1089/jir.2021.0078
发表时间： 2021-12-15
期刊： JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
影响因子： 2.607
货号： ZQ0424
产品名称： K562 cells
原文链接： https://www.liebertpub.com/doi/abs/10.1089/jir.2021.0078

论文标题： PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing
DOI： 10.1111/ijlh.13305
发表时间： 2020-10-02
期刊： International Journal of Laboratory Hematology
影响因子： 2.141
货号： ZQ0424
产品名称： K-562 cells

原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13305

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Nature 483:603-607(2012)

PubMed=22628656; DOI=10.1126/science.1218595
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Science 336:1040-1044(2012)

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