内皮细胞培养基是专门为正常人类微血管内皮细胞体外培养设计的适合其生长的完全培养基。是经灭菌的液体培养基，包含必需和非必需氨基酸、维生素、有机和无机化合物、激素、生长因子、微量矿物质和低浓度胎牛血清(5%)。该培养基缓冲体系为重碳酸盐，在含5%CO2的细胞培养箱中平衡后pH值为7.4。该培养基的配方能够选择性的促进正常人类微血管内皮细胞体外培养中的增殖和生长，并为其达到理想营养平衡状态。
        

  内皮细胞培养基包含500 ml基础培养基，25mll胎牛血清（FBS, Cat. No. 0025） 、5ml 内皮细胞生长因子（ECGS, Cat. No. 1052 ）、5 ml青霉素/链霉素溶液(P/S, Cat. No. 0503) 。

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20.) Chen, H., Tang, N., Chen, M. & Chen, D. (2016) Endothelialization of TiO2 Nanorods Coated with Ultrathin Amorphous Carbon Films Nanoscale Research Letters. 11

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22.) Zhou, S., Gao, L., Gong, F. & Chen, X. (2015) Receptor for advanced glycation end products involved in circulating endothelial cells release from human coronary endothelial cells induced by C-reactive protein Iran J Basic Med Sci. 18

23.) Zhang, E., Guo, Q., Gao, H., Xu, R., Teng, S. & Wu, Y. (2015) Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway PLoS One. 10

24.) Yuan, C., Wang, P., Zhu, L., Dissanayaka, W.L., Green, D.W., Tong, E.H., Jin, L. & Zhang, C. (2015) Coculture of Stem Cells from Apical Papilla and Human Umbilical Vein Endothelial Cell Under Hypoxia Increases the Formation of Three-Dimensional Vessel-Like Structures in Vitro Tissue Eng Part A. 21

25.) Ye, Q., Qin, S., Liu, Y., Feng, J., Wu, Q., Qu, W. & Yin, X. (2015) Inhibitory Effect of Endostar on Specific Angiogenesis Induced by Human Hepatocellular CarcinomaGastroenterol Res Pract. 2015

26.) Yang, Y., Chen, Q., Liu, A., Xu, X., Han, J. & Qiu, H. (2015) Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway Stem Cell Res Ther. 6

27.) Yang, G., Li, Y., Wu, W., Liu, B., Ni, L., Wang, Z., Miao, S., Wang, L. & Liu, C. (2015) Anti-oxidant effect of heme oxygenase-1 on cigarette smoke-induced vascular injuryMol Med Rep. 12

28.) Yang, B., Cai, B., Deng, P., Wu, X., Guan, Y., Zhang, B., Cai, W., Schaper, J. & Schaper, W. (2015) Nitric Oxide Increases Arterial Endotheial Permeability through Mediating VE-Cadherin Expression during Arteriogenesis PLoS One. 10

29.) Wurth, R., Tarn, K., Jernigan, D., Fernandez, S.V., Cristofanilli, M., Fatatis, A. & Meucci, O. (2015) A Preclinical Model of Inflammatory Breast Cancer to Study the Involvement of CXCR4 and ACKR3 in the Metastatic Process Transl Oncol. 8

30.) Wu, W., Xu, H., Wang, Z., Mao, Y., Yuan, L., Luo, W., Cui, Z., Cui, T., Wang, X.L. & Shen, Y.H. (2015) PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury PLoS One. 10

31.) Wang, K., Chen, X., Pan, Y., Cui, Y., Zhou, X., Kong, D. & Zhao, Q. (2015) Enhanced Vascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Release of VEGF Biomed Res Int. 2015

32.) Shi, J., Li, Y.J., Yan, B. & Wei, P.K. (2015) Interleukin-8: A potent promoter of human lymphatic endothelial cell growth in gastric cancer Oncol Rep. 33

33.) Menden, H., Welak, S., Cossette, S., Ramchandran, R. & Sampath, V. (2015) Lipopolysaccharide (LPS)-mediated Angiopoietin-2-dependent Autocrine Angiogenesis Is Regulated by NADPH Oxidase 2 (Nox2) in Human Pulmonary Microvascular Endothelial Cells* J Biol Chem. 290

34.) Lin, S., Nadeau, P.E. & Mergia, A. (2015) HIV inhibits endothelial reverse cholesterol transport through impacting subcellular Caveolin-1 trafficking Retrovirology. 12

35.) Li, Y., Zhou, S., Li, J., Sun, Y., Hasimu, H., Liu, R. & Zhang, T. (2015) Quercetin protects human brain microvascular endothelial cells from fibrillar ?-amyloid1?40-induced toxicity Acta Pharm Sin B. 5

36.) Li, X.P., Jing, W., Sun, J.J., Liu, Z.Y., Zhang, J.T., Sun, W., Zhu, W. & Fan, Y.Z. (2015) A potential small-molecule synthetic antilymphangiogenic agent norcantharidin inhibits tumor growth and lymphangiogenesis of human colonic adenocarcinomas through blocking VEGF-A,-C,-D/VEGFR-2,-3 ?multi-points priming? mechanisms in vitro and in vivo BMC Cancer. 15

37.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

38.) Lamichhane, S.P., Arya, N., Ojha, N., Kohler, E. & Shastri, V.P. (2015) Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake Int J Nanomedicine. 10

39.) Lau, Y.S., Ling, W.C., Murugan, D., Kwan, C.Y. & Mustafa, M.R. (2015) Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway Nutrients. 7

40.) Koudelkova, P., Weber, G. & Mikulits, W. (2015) Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF PLoS One. 10

41.) Jiang, Y.H., Sun, W., Li, W., Hu, H.Z., Zhou, L., Jiang, H.H. & Xu, J.X. (2015) Calycosin-7-O-?-D-glucoside promotes oxidative stress-induced cytoskeleton reorganization through integrin-linked kinase signaling pathway in vascular endothelial cells BMC Complement Altern Med. 15

42.) Jiang, F., Ma, J., Liang, Y., Niu, Y., Chen, N. & Shen, M. (2015) Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo Biomed Res Int. 2015

43.) Hu, C.T., Guo, L.L., Feng, N., Zhang, L., Zhou, N., Ma, L.L., Shen, L., Tong, G.H., Yan, Q.W., Zhu, S.J., Bian, X.W., Lai, M.D., Deng, Y.J. & Ding, Y.Q. (2015) MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis Oncotarget. 6

44.) Hesketh, A.J., Maloney, C., Behr, C.A., Edelman, M.C., Glick, R.D., Al-Abed, Y., Symons, M., Soffer, S.Z. & Steinberg, B.M. (2015) The Macrophage Inhibitor CNI-1493 Blocks Metastasis in a Mouse Model of Ewing Sarcoma through Inhibition of Extravasation PLoS One. 10

45.) Hempel, C., Boisen, I.M., Efunshile, A., Kurtzhals, J.A. & Staals?, T. (2015) An automated method for determining the cytoadhesion of Plasmodium falciparum-infected erythrocytes to immobilized cells Malar J. 14

46.) Giugliano, S., Kriss, M., Golden-Mason, L., Dobrinskikh, E., Stone, A.E., Soto-Gutierrez, A., Mitchell, A., Khetani, S.R., Yamane, D., Stoddard, M., Li, H., Shaw, G.M., Edwards, M.G., Lemon, S.M., Gale, M., Shah, V.H. & Rosen, H.R. (2015) HCV Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cell and Release of Exosomes, Which Inhibits Viral Replication Gastroenterology. 148

47.) Fu, Z., Chen, X., Guan, S., Yan, Y., Lin, H. & Hua, Z.C. (2015) Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway Oncotarget. 6

48.) Dissanayaka, W.L., Hargreaves, K.M., Jin, L., Samaranayake, L.P. & Zhang, C. (2015) The Interplay of Dental Pulp Stem Cells and Endothelial Cells in an Injectable Peptide Hydrogel on Angiogenesis and Pulp Regeneration In Vivo Tissue Eng Part A. 21

49.) Cai, X., Zhang, W., Chen, G., Li, R.F., Sun, Y.F. & Zhao, Y.F. (2015) Mesenchymal status of lymphatic endothelial cell: enlightening treatment of lymphatic malformation Int J Clin Exp Med. 8

50.) Bai, Y., Zhu, X., Chao, J., Zhang, Y., Qian, C., Li, P., Liu, D., Han, B., Zhao, L., Zhang, J., Buch, S., Teng, G., Hu, G. & Yao, H. (2015) Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke PLoS One. 10

51.) Zhou H, Ji X, Wu Y, Xuan J, Qi Z, Shen L, Lan L, Li Q, Yin Z, Li Z, Zhao Z. (2014) 'A Dual-Role of Gu-4 in Suppressing HMGB1 Secretion and Blocking HMGB1 Pro-Inflammatory Activity during Inflammation.'

52.) Zhao N, Watson N, Xu Z, Chen Y, Waterman J, Sankar J, Zhu D. (2014) 'In Vitro Biocompatibility and Endothelialization of Novel Magnesium-Rare Earth Alloys for Improved Stent Applications.'

53.) Yang J, Wang Q, Qiao C, Lin Z, Li X, Huang Y, Zhou T, Li Y, Shen B, Lv M, Feng J. (2014) 'Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60.'

54.) Xu Q, Xia P, Li X, Wang W, Liu Z, Gao X. (2014) 'Tetramethylpyrazine Ameliorates High Glucose-Induced Endothelial Dysfunction by Increasing Mitochondrial Biogenesis.'

55.) Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S. (2014) 'Salidroside Stimulates Mitochondrial Biogenesis and Protects against H 2 O 2-Induced Endothelial Dysfunction.'

56.) Voigt J, Christensen J, Shastri VP. (2014) 'Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae.'

57.) Wang Q, Yang J, Tang K, Luo L, Wang L, Tian L, Jiang Y, Feng J, Li Y, Shen B, Ly M, Huang Y. (2014) 'Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization.'

58.) Umar MI, Asmawi MZ, Sadikun A, Majid AMSA, Al-Suede FSR, Hassan LEA, Altaf R, Ahamed MBK. (2014) 'Ethyl-p-methoxycinnamate isolated from kaempferiagalanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-?, and angiogenesis by blocking endothelial functions.'

59.) Tong X, Lv P, Mathew AV, Liu D, Niu C, Wang Y, Ji L, Li J, Fu Z, Pan B, Pennathur S, Zheng L, Huang Y. (2014) 'The compensatory enrichment of sphingosine-1-phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus.'

60.) Liu Q, Hou J, Chen X, Liu G, Zhang D, Sun H, Zhang J. (2014) 'P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models.'

61.) Lim PJ, Chu JJH. (2014) 'A Polarized Cell Model for Chikungunya Virus Infection: Entry and Egress of Virus Occurs at the Apical Domain of Polarized Cells.'

62.) Guo W, Ding J, Zhang A, Dai W, Liu S, Diao Z, Wang L, Han X, Liu W. (2014) 'The Inhibitory Effect of Quercetin on Asymmetric Dimethylarginine-Induced Apoptosis Is Mediated by the Endoplasmic Reticulum Stress Pathway in Glomerular Endothelial Cells.'

63.) AbuBakar S, Shu MH, Johari J, Wong PF. (2014) 'Senescence Affects Endothelial Cells Susceptibility to Dengue Virus Infection.'

64.) Adams Y, Kuhnrae P, Higgins MK, Ghumra A, Rowe JA. (2014) 'Rosetting Plasmodium falciparum-Infected Erythrocytes Bind to Human Brain Microvascular Endothelial Cells In Vitro, Demonstrating a Dual Adhesion Phenotype Mediated by Distinct P. falciparum Erythrocyte Membrane Protein 1 Domains.'

65.) AbuBakar S, Shu MH, Johari J, Wong PF. (2014) "Senescence Affects Endothelial Cells Susceptibility to Dengue Virus Infection." Int j med sci. 11: 538.

66.) Adams Y, Kuhnrae P, Higgins MK, Ghumra A, Rowe JA. (2014) "Rosetting Plasmodium falciparum-Infected Erythrocytes Bind to Human Brain Microvascular Endothelial Cells In Vitro, Demonstrating a Dual Adhesion Phenotype Mediated by Distinct P. falciparum Erythrocyte Membrane Protein 1 Domains." Infect immune. 82: 949-59.

67.) Guo W, Ding J, Zhang A, Dai W, Liu S, Diao Z, Wang L, Han X, Liu W. (2014) "The Inhibitory Effect of Quercetin on Asymmetric Dimethylarginine-Induced Apoptosis Is Mediated by the Endoplasmic Reticulum Stress Pathway in Glomerular Endothelial Cells." Int j mol sci. 15: 484-503.

68.) Lim PJ, Chu JJH. (2014) "A Polarized Cell Model for Chikungunya Virus Infection: Entry and Egress of Virus Occurs at the Apical Domain of Polarized Cells." PLoSnegl trop dis. 8: e2661.

69.) Liu Q, Hou J, Chen X, Liu G, Zhang D, Sun H, Zhang J. (2014) "P-Glycoprotein Mediated Efflux Limits the Transport of the Novel Anti-Parkinson's Disease Candidate Drug FLZ across the Physiological and PD Pathological In Vitro BBB Models." PloS one. 9: e102442.

70.) Tong X, Lv P, Mathew AV, Liu D, Niu C, Wang Y, Ji L, Li J, Fu Z, Pan B, Pennathur S, Zheng L, Huang Y. (2014) "The compensatory enrichment of sphingosine-1-phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus." Cardiovascdiabetol. 13: 82.

71.) Umar MI, Asmawi MZ, Sadikun A, Majid AMSA, Al-Suede FSR, Hassan LEA, Altaf R, Ahamed MBK. (2014) "Ethyl-p-methoxycinnamate isolated from kaempferiagalanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-&aplha;, and angiogenesis by blocking endothelial functions." Clinics. 69: 134-44.

72.) Voigt J, Christensen J, Shastri VP. (2014) "Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae." ProcNatlAcad Sci. 111: 2942-47.

73.) Wang Q, Yang J, Tang K, Luo L, Wang L, Tian L, Jiang Y, Feng J, Li Y, Shen B, Ly M, Huang Y. (2014) "Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization." BMC biotechnol. 14: 17.

74.) Xing S, Yang X, Li W, Bian F, Wu D, Chi J, Xu G, Zhang Y, Jin S. (2014) "Salidroside Stimulates Mitochondrial Biogenesis and Protects against H 2 O 2-Induced Endothelial Dysfunction." Oxid med cell longev. 2014: 904834.

75.) Xu Q, Xia P, Li X, Wang W, Liu Z, Gao X. (2014) "Tetramethylpyrazine Ameliorates High Glucose-Induced Endothelial Dysfunction by Increasing Mitochondrial Biogenesis." PloS one. 9: e88243.

76.) Yang J, Wang Q, Qiao C, Lin Z, Li X, Huang Y, Zhou T, Li Y, Shen B, Lv M, Feng J. (2014) "Potent anti-angiogenesis and anti-tumor activity of a novel human anti-VEGF antibody, MIL60." Cell molimmunol. 11: 285-93.

77.) Zhao N, Watson N, Xu Z, Chen Y, Waterman J, Sankar J, Zhu D. (2014) "In Vitro Biocompatibility and Endothelialization of Novel Magnesium-Rare Earth Alloys for Improved Stent Applications." PloS one. 9: e98674.

78.) Zhou H, Ji X, Wu Y, Xuan J, Qi Z, Shen L, Lan L, Li Q, Yin Z, Li Z, Zhao Z. (2014) "A Dual-Role of Gu-4 in Suppressing HMGB1 Secretion and Blocking HMGB1 Pro-Inflammatory Activity during Inflammation." PloS one. 9: e89634.

79.) Jandu SK, Webb AK, Pak A, Sevinc B, Nyhan D, Belkin AM, Flavahan NA, Berkowitz DE, Santhanam L. (2013) Nitric oxide regulates tissue transglutaminase localization and function in the vasculature. Amino Acids. 44: 261-9.

80.) Cucullo L, Hossain M, Tierney M, Janigro D. (2013) "A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box." BMC Neurosci. 14: 18.

81.) Guo W, Zhang D, Wang X, Kong W, Zhang Q, Zhang Y, Liu W. (2013) "Actin cytoskeleton modulates ADMA-induced NF-kappaB nuclear translocation and ICAM-1 expression in endothelial cells." Med Sci Monit. 17: BR242

82.) Tong X, Peng H, Liu D, Ji L, Niu C, Ren J, Pan B, Hu J, Zheng L, Huang Y. (2013) "High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate." Cardiovasc Diabetol. 12: 27.

83.) Yue X, Xu L, Zhu M, Zhang R, Liu C. (2013) "Over-expression of Nerve Growth Factor-α in human cholangiocarcinoma QBC939 cells promote tumor progression." PLoS One. 8: e62024.

84.) Crowe A, Jackaman C, Beddoes KM, Ricciardo B, Nelson DJ. (2013) "Rapid copper acquisition by developing murine mesothelioma: decreasing bioavailable copper slows tumor growth, normalizes vessels and promotes T cell infiltration." PLoS One. 8: e73684.

85.) Zhao XC, Dou GR, Wang L, Liang L, Tian DM, Cao XL, Qin HY, Wang CM, Zhang P, Han H. (2013) "Inhibition of Tumor Angiogenesis and Tumor Growth by the DSL Domain of Human Delta-Like 1 Targeted to Vascular Endothelial Cells." Neoplasia. 15 :815-25

86.) Lachance PA, Hazen A, Sevick-Muraca EM. (2013) "Lymphatic Vascular Response to Acute Inflammation." PLoS One. 8: e76078.

87.) Aisha AF, Ismail Z, Abu-Salah KM, Siddiqui JM, Ghafar G, Abdul Majid AM. (2013) "Syzygium campanulatum korth methanolic extract inhibits angiogenesis and tumor growth in nude mice" BMC Complement Altern Med. 13: 168. 

88.) Cheng HS, Sivachandran N, Lau A, Boudreau E, Zhao JL, Baltimore D, Delgado-Olguin P, Cybulsky MI, Fish JE. (2013) "MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways." EMBO Mol Med. 5: 1017-34. 

89.) Zhang W, Ni C, Sheng J, Hua Y, Ma J, Wang L, Zhao Y, Xing Y. (2013) 'TLQP-21 Protects Human Umbilical Vein Endothelial Cells against High-Glucose-Induced Apoptosis by Increasing G6PD Expression.'

90.) Zhang S, Liu L, Wang R, Tuo H, Guo Y, Yi L, Wang D, Wang J. (2013) 'MicroRNA-217 Promotes Angiogenesis of Human Cytomegalovirus-Infected Endothelial Cells through Downregulation of SIRT1 and FOXO3A.'

91.) Wu M, Zhao D, Zhong W, Yan H, Wang X, Liang Z, Li Z. (2013) 'High-density distributed electrode network, a multi-functional electroporation method for delivery of molecules of different sizes.'

92.) Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y, Wu G. (2013) 'MiR-200c Increases the Radiosensitivity of Non-Small-Cell Lung Cancer Cell Line A549 by Targeting VEGF-VEGFR2 Pathway.'

93.) Muniz-Feliciano L, Van GJ, Portillo JAC, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS. (2013) 'Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite.'

94.) Kong X, Zhang Y, Liu C, Guo W, Li X, Su X, Wan H, Sun Y, Lin, N. (2013) 'Anti-Angiogenic Effect of Triptolide in Rheumatoid Arthritis by Targeting Angiogenic Cascade.'

95.) Kong X, Zhang Y, Liu C, Guo W, Li X, Su X, Wan H, Sun Y, Lin, N. (2013) "Anti-Angiogenic Effect of Triptolide in Rheumatoid Arthritis by Targeting Angiogenic Cascade."PloS one. 8: e77513.

96.) Muniz-Feliciano L, Van GJ, Portillo JAC, Liew L, Liu B, Carlin CR, Carruthers VB, Matthews S, Subauste CS. (2013) "Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite." PLoSPathog. 9: e1003809.

97.) Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y, Wu G. (2013) "MiR-200c Increases the Radiosensitivity of Non-Small-Cell Lung Cancer Cell Line A549 by Targeting VEGF-VEGFR2 Pathway." PloS one

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