产品名称	Thp-1人单核细胞白血病
货号	ZQ0086
产品介绍	THP-1是一种人急性单核细胞白血病细胞系，最初从一位1岁患有急性单核细胞白血病的男孩的外周血中分离出来的单核细胞。该细胞对乳汁珠和激活的红细胞有吞噬作用，无表面和胞质免疫球蛋白。 可以用佛波醇 TPA诱导单核细胞分化。表达C3R和FcR；可作为转染宿主。也因其能够被诱导分化成单核/巨噬细胞，所以在免疫学研究中具有广泛的应用。例如：巨噬细胞分化与炎症模型、基因编辑研究、免疫调节作用研究、疾病模型构建与药物筛选、STING激动剂筛选模型、细胞凋亡和细胞周期研究、表观遗传调控研究等。这些应用展示了THP-1细胞系在免疫学研究中的多样性和重要性，为理解免疫调节和疾病机制提供了宝贵的工具。 【注意事项】： 1. 该细胞为悬浮细胞。根据我司培养经验，建议传代时使用【半换液法】对细胞状态有利。请不要通过离心的方式收集细胞，可以直接向培养瓶中添加等体积的新鲜培养液，然后将细胞吹打均匀后移入两个新的T25培养瓶中继续培养即可（1:2传代）。 2. 该细胞在培养过程中，可能会有少量贴壁或聚集成小团生长，属于正常情况。传代时可以轻轻打散，如少许细胞已贴壁则传代时丢弃，小团生长的细胞正常传代培养即可。 3. 该细胞对细胞密度较为敏感，培养、传代时请注意保持细胞密度在合适的范围。 4.  该细胞较难复苏，复苏后需要约7天左右才可能恢复至正常状态。刚复苏后，细胞生长缓慢且会出现黑色细胞碎片，少量细胞碎片不影响细胞正常生长，待细胞恢复生长后用半换液法可以稀释碎片。 5. 细胞冻存时务请提高细胞密度，建议1个T25培养瓶中含有3-5×106细胞量时冻存一支。 6. 该细胞对血清质量较为敏感，我司建议您使用优质胎牛血清进行培养或选择订购我司配套THP-1完全培养液。
种属	人
性别/年龄	男/1岁
组织	外周血
疾病	急性单核细胞白血病
细胞类型	肿瘤细胞
形态学	单核细胞
生长方式	悬浮
倍增时间	大约26~70小时
培养基和添加剂	RPMI-1640（中乔新舟 货号：ZQ-200）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%双抗（中乔新舟   货号：CSP006）+β-Mer 终浓度：0.05mM（中乔新舟  货号：CSP005，例：500ml添加500ul）
推荐完全培养基货号	ZM0086
生物安全等级	BSL-1
STR位点信息	Amelogenin: X,Y CSF1PO: 11,13 D13S317: 13 D16S539: 11,12 D5S818: 11,12 D7S820: 10 TH01: 8,9.3 TPOX: 8,11 vWA: 16 D3S1358: 15,17 D21S11: 30,31.2 D18S51: 13,14 D8S1179: 10,14 FGA: 24,25 D19S433: 12.2,13 D2S1338: 17,18
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; TIB-202 DSMZ; ACC-16 ECACC; 88081201
供应限制	仅供科研使用

货号	ZQ0086
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis
DOI： 10.1093/bib/bbab210
发表时间： 2021-11-05
期刊： BRIEFINGS IN BIOINFORMATICS
影响因子： 11.622
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://academic.oup.com/bib/article-abstract/22/6/bbab210/6309357

论文标题： 45S5 Bioglass® works synergistically with siRNA to downregulate the expression of matrix metalloproteinase-9 in diabetic wounds
DOI： 10.1016/j.actbio.2022.04.010
发表时间： 2022-04-12
期刊： Acta Biomaterialia
影响因子： 8.947
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S1742706122002148

论文标题： Calcium silicate enhances immunosuppressive function of MSCs to indirectly modulate the polarization of macrophages
DOI： 10.1093/rb/rbab056
发表时间： 2021-09-02
期刊： Regenerative Biomaterials
影响因子： 6.353
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://academic.oup.com/rb/article-abstract/8/6/rbab056/6408453

论文标题： Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron
DOI： 10.1016/j.bcp.2021.114436
发表时间： 2021-02-01
期刊： BIOCHEMICAL PHARMACOLOGY
影响因子： 5.858
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0006295221000320

论文标题： The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia
DOI： 10.1016/j.bcp.2022.114948
发表时间： 2022-02-19
期刊： BIOCHEMICAL PHARMACOLOGY
影响因子： 5.858
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0006295222000429

论文标题： A novel role of VEPH1 in regulating AoSMC phenotypic switching
DOI： 10.1002/jcp.29736
发表时间： 2020-04-27
期刊： JOURNAL OF CELLULAR PHYSIOLOGY
影响因子： 5.546
货号： ZQ0086
产品名称： THP1 cells

原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29736

论文标题： AT1R Regulates Macrophage Polarization Through YAP and Regulates Aortic Dissection Incidence
DOI： 10.3389/fphys.2021.644903
发表时间： 2021-07-09
期刊： Frontiers in Physiology
影响因子： 4.566
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8299470/

论文标题： Knockdown of periostin attenuates 5/6 nephrectomy‐induced intrarenal renin–angiotensin system activation, fibrosis, and inflammation in rats
DOI： 10.1002/jcp.28849
发表时间： 2019-05-24
期刊： JOURNAL OF CELLULAR PHYSIOLOGY
影响因子： 4.522
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28849

论文标题： MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1
DOI： 10.1016/j.yjmcc.2020.04.008
发表时间： 2020-04-09
期刊： JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
影响因子： 4.133
货号： ZQ0086
产品名称： THP-1 monocytes
原文链接： https://www.sciencedirect.com/science/article/pii/S0022282820300900

论文标题： Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages
DOI： 10.1007/s10753-021-01551-7
发表时间： 2021-09-03
期刊： INFLAMMATION
影响因子： 4.092
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://link.springer.com/article/10.1007/s10753-021-01551-7

论文标题： mTORC1 signaling pathway regulates macrophages in choroidal neovascularization
DOI： 10.1016/j.molimm.2020.03.002
发表时间： 2020-03-12
期刊： MOLECULAR IMMUNOLOGY
影响因子： 3.641
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0161589019308636

论文标题： SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18
DOI： 10.1016/j.bbrc.2021.05.011
发表时间： 2021-05-15
期刊： BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子： 3.575
货号： ZQ0086
产品名称： THP-1 monocytes
原文链接： https://www.sciencedirect.com/science/article/pii/S0006291X21007816

论文标题： MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis
DOI： 10.1155/2020/8864322
发表时间： 2020-11-18
期刊： DISEASE MARKERS
影响因子： 2.738
货号： ZQ0086
产品名称： THP-1 monocytes
原文链接： https://www.hindawi.com/journals/dm/2020/8864322/

论文标题： Comparative Analysis of Chemical Composition andAntibacterial and Anti-Inflammatory Activities of theEssential Oils from Chrysanthemum morifolium ofDifferent Flowering Stages and Different Parts
DOI： 10.1155/2022/5954963
发表时间： 2022-06-06
期刊： Evidence-based Complementary and Alternative Medicine
影响因子： 2.65
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.hindawi.com/journals/ecam/2022/5954963/

论文标题： Alteration of liver immunity by increasing inflammatory response during co-administration of methamphetamine and atazanavir
DOI： 10.1080/08923973.2020.1745829
发表时间： 2020-04-06
期刊： IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
影响因子： 2.352
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.tandfonline.com/doi/abs/10.1080/08923973.2020.1745829

论文标题： PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing
DOI： 10.1111/ijlh.13305
发表时间： 2020-10-02
期刊： International Journal of Laboratory Hematology
影响因子： 2.141
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13305

论文标题： Long non‑coding RNA MALAT1 regulates cholesterol accumulation in ox‑LDL‑induced macrophages via the microRNA‑17‑5p/ABCA1 axis
DOI： 10.3892/mmr.2020.10987
发表时间： 2020-04-01
期刊： Molecular Medicine Reports
影响因子： 2.1
货号： ZQ0086
产品名称： THP-1 cells
原文链接： https://www.spandidos-publications.com/10.3892/mmr.2020.10987

论文标题： Effect of HMGB1 on monocyte immune function in respiratory syncytial virus bronchiolitis
DOI： 10.3892/etm.2020.9507
发表时间： 2020-11-25
期刊： Experimental and Therapeutic Medicine
影响因子： 1.785
货号： ZQ0086
产品名称： THP-1 monocytes
原文链接： https://www.spandidos-publications.com/10.3892/etm.2020.9507

论文标题： Silencing p62 reduces ox-LDL-induced M1 polarization and inflammation in macrophages by inhibiting mTOR/NF-κB signaling pathways:
DOI： 10.1177/1721727X221110348
发表时间： 2022-07-16
期刊： European Journal of Inflammation
影响因子： 0.424
货号： ZQ0086
产品名称： THP-1 monocytes

原文链接： https://journals.sagepub.com/doi/abs/10.1177/1721727X221110348

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