产品名称 |
Thp-1人单核细胞白血病 |
货号 |
ZQ0086 |
产品介绍 |
THP-1是一种人急性单核细胞白血病细胞系,最初从一位1岁患有急性单核细胞白血病的男孩的外周血中分离出来的单核细胞。该细胞对乳汁珠和激活的红细胞有吞噬作用,无表面和胞质免疫球蛋白。 可以用佛波醇 TPA诱导单核细胞分化。表达C3R和FcR;可作为转染宿主。也因其能够被诱导分化成单核/巨噬细胞,所以在免疫学研究中具有广泛的应用。例如:巨噬细胞分化与炎症模型、基因编辑研究、免疫调节作用研究、疾病模型构建与药物筛选、STING激动剂筛选模型、细胞凋亡和细胞周期研究、表观遗传调控研究等。这些应用展示了THP-1细胞系在免疫学研究中的多样性和重要性,为理解免疫调节和疾病机制提供了宝贵的工具。
【注意事项】: |
种属 |
人 |
性别/年龄 |
男/1岁 |
组织 |
外周血 |
疾病 |
急性单核细胞白血病 |
细胞类型 |
肿瘤细胞 |
形态学 |
单核细胞 |
生长方式 |
悬浮 |
倍增时间 |
大约26~70小时 |
培养基和添加剂 |
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%双抗(中乔新舟 货号:CSP006)+β-Mer 终浓度:0.05mM(中乔新舟 货号:CSP005,例:500ml添加500ul) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin: X,Y
CSF1PO: 11,13
|
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
ATCC; TIB-202 DSMZ; ACC-16 ECACC; 88081201 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0086 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
论文标题: Exosomal ncRNAs profiling of mycobacterial infection identified miRNA-185-5p as a novel biomarker for tuberculosis
DOI: 10.1093/bib/bbab210
发表时间: 2021-11-05
期刊: BRIEFINGS IN BIOINFORMATICS
影响因子: 11.622
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://academic.oup.com/bib/article-abstract/22/6/bbab210/6309357
论文标题: 45S5 Bioglass® works synergistically with siRNA to downregulate the expression of matrix metalloproteinase-9 in diabetic wounds
DOI: 10.1016/j.actbio.2022.04.010
发表时间: 2022-04-12
期刊: Acta Biomaterialia
影响因子: 8.947
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S1742706122002148
论文标题: Calcium silicate enhances immunosuppressive function of MSCs to indirectly modulate the polarization of macrophages
DOI: 10.1093/rb/rbab056
发表时间: 2021-09-02
期刊: Regenerative Biomaterials
影响因子: 6.353
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://academic.oup.com/rb/article-abstract/8/6/rbab056/6408453
论文标题: Eltrombopag inhibits Type I interferon-mediated antiviral signaling by decreasing cellular iron
DOI: 10.1016/j.bcp.2021.114436
发表时间: 2021-02-01
期刊: BIOCHEMICAL PHARMACOLOGY
影响因子: 5.858
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0006295221000320
论文标题: The new mitochondrial uncoupler BAM15 induces ROS production for treatment of acute myeloid leukemia
DOI: 10.1016/j.bcp.2022.114948
发表时间: 2022-02-19
期刊: BIOCHEMICAL PHARMACOLOGY
影响因子: 5.858
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0006295222000429
论文标题: A novel role of VEPH1 in regulating AoSMC phenotypic switching
DOI: 10.1002/jcp.29736
发表时间: 2020-04-27
期刊: JOURNAL OF CELLULAR PHYSIOLOGY
影响因子: 5.546
货号: ZQ0086
产品名称: THP1 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.29736
论文标题: AT1R Regulates Macrophage Polarization Through YAP and Regulates Aortic Dissection Incidence
DOI: 10.3389/fphys.2021.644903
发表时间: 2021-07-09
期刊: Frontiers in Physiology
影响因子: 4.566
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8299470/
论文标题: Knockdown of periostin attenuates 5/6 nephrectomy‐induced intrarenal renin–angiotensin system activation, fibrosis, and inflammation in rats
DOI: 10.1002/jcp.28849
发表时间: 2019-05-24
期刊: JOURNAL OF CELLULAR PHYSIOLOGY
影响因子: 4.522
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.28849
论文标题: MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1
DOI: 10.1016/j.yjmcc.2020.04.008
发表时间: 2020-04-09
期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
影响因子: 4.133
货号: ZQ0086
产品名称: THP-1 monocytes
原文链接: https://www.sciencedirect.com/science/article/pii/S0022282820300900
论文标题: Supervillin Contributes to LPS-induced Inflammatory Response in THP-1 Cell-derived Macrophages
DOI: 10.1007/s10753-021-01551-7
发表时间: 2021-09-03
期刊: INFLAMMATION
影响因子: 4.092
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://link.springer.com/article/10.1007/s10753-021-01551-7
论文标题: mTORC1 signaling pathway regulates macrophages in choroidal neovascularization
DOI: 10.1016/j.molimm.2020.03.002
发表时间: 2020-03-12
期刊: MOLECULAR IMMUNOLOGY
影响因子: 3.641
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.sciencedirect.com/science/article/pii/S0161589019308636
论文标题: SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18
DOI: 10.1016/j.bbrc.2021.05.011
发表时间: 2021-05-15
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.575
货号: ZQ0086
产品名称: THP-1 monocytes
原文链接: https://www.sciencedirect.com/science/article/pii/S0006291X21007816
论文标题: MicroRNA-216a Promotes Endothelial Inflammation by Smad7/IκBα Pathway in Atherosclerosis
DOI: 10.1155/2020/8864322
发表时间: 2020-11-18
期刊: DISEASE MARKERS
影响因子: 2.738
货号: ZQ0086
产品名称: THP-1 monocytes
原文链接: https://www.hindawi.com/journals/dm/2020/8864322/
论文标题: Comparative Analysis of Chemical Composition andAntibacterial and Anti-Inflammatory Activities of theEssential Oils from Chrysanthemum morifolium ofDifferent Flowering Stages and Different Parts
DOI: 10.1155/2022/5954963
发表时间: 2022-06-06
期刊: Evidence-based Complementary and Alternative Medicine
影响因子: 2.65
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.hindawi.com/journals/ecam/2022/5954963/
论文标题: Alteration of liver immunity by increasing inflammatory response during co-administration of methamphetamine and atazanavir
DOI: 10.1080/08923973.2020.1745829
发表时间: 2020-04-06
期刊: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
影响因子: 2.352
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.tandfonline.com/doi/abs/10.1080/08923973.2020.1745829
论文标题: PCAT18, as a novel differentially regulated long noncoding RNA in adult acute myeloid leukemia patients revealed by next-generation sequencing
DOI: 10.1111/ijlh.13305
发表时间: 2020-10-02
期刊: International Journal of Laboratory Hematology
影响因子: 2.141
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1111/ijlh.13305
论文标题: Long non‑coding RNA MALAT1 regulates cholesterol accumulation in ox‑LDL‑induced macrophages via the microRNA‑17‑5p/ABCA1 axis
DOI: 10.3892/mmr.2020.10987
发表时间: 2020-04-01
期刊: Molecular Medicine Reports
影响因子: 2.1
货号: ZQ0086
产品名称: THP-1 cells
原文链接: https://www.spandidos-publications.com/10.3892/mmr.2020.10987
论文标题: Effect of HMGB1 on monocyte immune function in respiratory syncytial virus bronchiolitis
DOI: 10.3892/etm.2020.9507
发表时间: 2020-11-25
期刊: Experimental and Therapeutic Medicine
影响因子: 1.785
货号: ZQ0086
产品名称: THP-1 monocytes
原文链接: https://www.spandidos-publications.com/10.3892/etm.2020.9507
论文标题: Silencing p62 reduces ox-LDL-induced M1 polarization and inflammation in macrophages by inhibiting mTOR/NF-κB signaling pathways:
DOI: 10.1177/1721727X221110348
发表时间: 2022-07-16
期刊: European Journal of Inflammation
影响因子: 0.424
货号: ZQ0086
产品名称: THP-1 monocytes
原文链接: https://journals.sagepub.com/doi/abs/10.1177/1721727X221110348
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