产品名称 |
B-CPAP人甲状腺癌细胞 |
货号 |
ZQ0304 |
产品介绍 |
B-CPAP 是一种人类乳头状甲状腺癌细胞系,于1992年从一名罹患转移性甲状腺乳头状癌的76岁女性的肿瘤组织中建立。该细胞系表现出上皮样形态,常用于研究甲状腺癌生物学,包括肿瘤发生和转移机制。B-CPAP 细胞因携带 BRAF V600E 突变而著名,这是一种与侵袭性甲状腺癌相关的常见基因变异,是评估 BRAF 抑制剂作为治疗剂的关键模型。 除了 BRAF 突变外,B-CPAP 细胞还表达甲状腺特异性标志物,如甲状腺球蛋白和促甲状腺激素受体,使其成为研究甲状腺功能和病理的宝贵模型。它们已广泛用于研究与甲状腺癌进展有关的信号通路,包括 MAPK/ERK 通路激活。这些细胞还用于药物耐药性和细胞凋亡研究,为甲状腺癌治疗失败的机制提供了见解。 |
种属 |
人 |
性别/年龄 |
女/76岁 |
组织 |
甲状腺 |
疾病 |
甲状腺癌 |
细胞类型 |
肿瘤细胞 |
形态学 |
纺锤状或圆形细胞贴壁生长成单层细胞 |
生长方式 |
贴壁 |
倍增时间 |
大约30小时 |
培养基和添加剂 |
RPMI-1640(中乔新舟 货号:ZQ-200)+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟 货号:CSP006)+1%Non-essential Amino Acids, 100X (中乔新舟 货号:CSP008)+ +1% Sodium Pyruvate 100 mM Solution(中乔新舟 货号:CSP003)+1%L-alanyl-L-glutamine(中乔新舟 货号:CSP004) |
推荐完全培养基货号 |
|
生物安全等级 |
BSL-1 |
STR位点信息 |
Amelogenin: X;
CSF1PO: 13 |
培养条件 |
95%空气,5%二氧化碳;37℃ |
抗原表达/受体表达 |
*** |
基因表达 |
*** |
保藏机构 |
DSMZ; ACC-273 |
供应限制 |
仅供科研使用 |
货号 |
ZQ0304 |
发货规格 |
活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一 |
发货形式 |
活细胞:常温运输;冻存管:干冰运输 |
储存温度 |
活细胞:培养箱;冻存管:液氮罐 |
产地 |
中国 |
供应限制 |
仅供科研使用 |
论文标题: Hypomethylated gene RAC3 induces cell proliferation and invasion by increasing FASN expression in endometrial cancer
DOI:10.1016/j.biocel.2022.106274. Epub 2022 Jul 30
发表时间: 2022-8-1
期刊: The International Journal of Biochemistry & Cell Biology
影响因子: 3.4
货号: ZQ0304
产品名称: BCPAP cells
原文链接:https://www.sciencedirect.com/science/article/abs/pii/S1357272522001194?via%3Dihub
论文标题: Identification and Application of an Aptamer Targeting Papillary Thyroid Carcinoma Using Tissue-SELEX
DOI: 10.1021/acs.analchem.9b01000原文链接: https://pubs.acs.org/doi/abs/10.1021/acs.analchem.9b01000
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PubMed=20164919; DOI=10.1038/nature08768
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Nature 463:893-898(2010)
PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)
PubMed=22087789; DOI=10.1186/1755-8166-4-26
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Mol. Cytogenet. 4:26.1-26.8(2011)
PubMed=22460905; DOI=10.1038/nature11003
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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)
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PubMed=23833040; DOI=10.1210/jc.2013-2383
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Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
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A resource for cell line authentication, annotation and quality control.
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A landscape of pharmacogenomic interactions in cancer.
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Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells.
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产品名称 | 价格 | 指令 |
TTA1人甲状腺癌细胞(STR鉴定) | ¥1500.00 | 购物车 》 |
8305C人甲状腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
ACT-1人甲状腺癌细胞(STR鉴定) | ¥1500.00 | 购物车 》 |
CAL-62人甲状腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
BHT101人甲状腺癌细胞(STR鉴定) | ¥1800.00 | 购物车 》 |
HTh-7人甲状腺癌细胞(STR鉴定)[套餐促销] | ¥1200.00 | 购物车 》 |
Hth83人甲状腺癌细胞(STR鉴定) | ¥1600.00 | 购物车 》 |
KHM-5M人甲状腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
KMH-2人甲状腺癌细胞(STR鉴定) | ¥1500.00 | 购物车 》 |
KTC-1人甲状腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
Ocut-2C人甲状腺癌细胞(STR鉴定) | ¥1600.00 | 购物车 》 |
C643人甲状腺癌细胞(STR鉴定)[套餐促销] | ¥1350.00 | 购物车 》 |
国产转染试剂 | ¥800.00 | 购物车 》 |
慢病毒介导基因沉默或过表达 | ¥询价 | 购物车 》 |
国产优级胎牛血清 | ¥1800.00 | 购物车 》 |
细菌基因敲除 | ¥询价 | 购物车 》 |
RPMI-1640基础培养基 | ¥56.00 | 购物车 》 |
RPMI-1640完全培养基 | ¥350.00 | 购物车 》 |