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Caki-1人肾透明细胞癌皮肤转移细胞(STR鉴定)[套餐促销]
英文名:Caki-1
货号:ZQ0339
价格:¥1600.00
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Caki-1人肾透明细胞癌皮肤转移细胞(STR鉴定)[套餐促销]

¥1600.00
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Caki-1人肾透明细胞癌皮肤转移细胞专用培养基

¥350.00 ¥500.00

配套完培,组合使用,省时省力

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细胞套餐惊爆价

¥1950 ¥2100.00
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

Caki-1人肾透明细胞癌皮肤转移细胞

货号

ZQ0339

产品介绍

Caki-1细胞系来源于人肾透明细胞癌的转移部位。Caki-1细胞来源于一名男性患者肾静脉壁上的肿瘤,该细胞超微结构特征包括许多微绒毛、少量丝状体、许多小线粒体、发达的高尔基体和内质网、许多脂滴和多层体、次级溶酶体、无病毒颗粒。常用于肾癌生物学的研究,特别是在了解透明细胞肾细胞癌(ccRCC)的机制方面。该细胞系在形态上呈上皮样,并表现出强大的体外生长特性,使其适用于各种实验技术,包括药物筛选和分子生物学研究。
Caki-1因其复杂的核型而特别引人注目,其特征是模态染色体数为68,变异范围为63至71。这种非整倍体染色体结构突出了具有某些异常的三倍体范围;值得注意的是,Y染色体缺失,这在男性来源的肿瘤细胞系中并不罕见。该细胞系显示出一些染色体畸变,包括多个标记染色体和染色体N5、N9、N10、N16和N19的改变,有助于其在癌症研究中的应用。
在致瘤性方面,Caki-1能够在裸鼠体内形成肿瘤,并有报道称其持续产生透明细胞癌,反映了肾原发肿瘤的病理。这一特性使其成为肾癌转移和肿瘤生物学体内研究的宝贵模型。在实验环境中也观察到细胞系转移到皮肤。从生化角度来看,Caki-1表达多种同工酶和抗原,包括血型O、Rh-和HLA型A9、B12、Bw35。同工酶谱包括AK-1、ES-D、G6PD B、gloi、Me-2、PGM1和PGM3,它们可能与研究与癌症进展和治疗反应相关的细胞代谢和基因表达有关。

种属

性别/年龄

男/49岁

组织

肾;来源于转移部位:皮肤

疾病

明细胞癌

细胞类型

肿瘤细胞 

形态学

上皮的

生长方式

贴壁

倍增时间

大约36~60小时 

培养基和添加剂

McCOY's 5A(中乔新舟  货号:ZQ-1000+10%胎牛血清(中乔新舟 货号:ZQ0500)+1%P/S(中乔新舟  货号:CSP006

推荐完全培养基货号

ZM0339

生物安全等级

BSL-1

STR位点信息

Amelogenin: X

CSF1PO: 10,11

D13S317: 11,12

D16S539: 12

D5S818: 11,12

D7S820: 8,12

TH01: 6,8

TPOX: 8,11

vWA: 15,17

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

 ***

基因表达

 ***

保藏机构

ATCC; HTB-46 DSMZ; ACC-142 DSMZ; ACC-731

供应限制

仅供科研使用

货号

ZQ0339

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


论文标题: Identification of Prognostic Metabolism-Related Genes in Clear Cell Renal Cell Carcinoma
DOI: 10.1155/2021/2042114
发表时间: 2021-09-27
期刊: Journal of Oncology
影响因子: 4.375
货号: ZQ0339
产品名称: Caki-1 cells
原文链接: https://www.hindawi.com/journals/jo/2021/2042114/


论文标题: Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma
DOI: 10.20892/j.issn.2095-3941.2020.0186
发表时间: 2021-02-15
期刊: Cancer Biology & Medicine
影响因子: 4.248
货号: ZQ0339
产品名称: Caki-1 cells
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877181/


论文标题: Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma
DOI: 10.1016/j.prp.2021.153622
发表时间: 2021-09-20
期刊: PATHOLOGY RESEARCH AND PRACTICE
影响因子: 3.25
货号: ZQ0339
产品名称: Caki-1 cells

原文链接: https://www.sciencedirect.com/science/article/pii/S0344033821002831



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