产品名称	HCC1937人乳腺癌细胞
货号	ZQ0367
产品介绍	这株细胞1995年10月13日最初来源于原发性导管癌, 用了11.5个月建株。肿瘤分类为TNM IIB期, 3级。 BRCA1分析表明这株细胞是BRCA1 5382C突变纯合的, 而来源于同一病人的类淋巴母细胞细胞株在这个突变位点上是杂合的。 另两个家庭成员也有这个突变; 一个同卵双生姐妹也患有乳腺癌。这株细胞有一个后天的TP53突变, 而其野生型等位基因丢失; 一个PTEN基因的后天的纯合缺失, 以及多个与乳腺癌发病机理相关的位点上发生的杂合突变。这株细胞Her2-neu和p53表达都呈阴性。 HCC1937的上皮细胞特异性标志上皮细胞糖蛋2(EGP2)和细胞角蛋白19都呈阳性。雌激素受体(ER)和孕酮(PR)表达阴性。来源于同一患者的EBV转化的类淋巴母细胞株(HCC1937BL)也有供应, ATCC目录号为CRL-2337。 注意事项： HCC1937细胞难消化且生长较慢，该细胞形态不均一呈不规则形状，有一些含有液泡的巨大细胞，该细胞胞体有黑色颗粒物，且分泌少量黑点属正常现象。细胞密度过高会有圆细胞漂浮是正常现象
种属	人
性别/年龄	女/23岁
组织	乳腺；乳房/导管
疾病	TNM IIB分期，3级，原发性导管癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁（线状生长为大的上皮细胞，倾向于以高细胞密度漂浮）
倍增时间	大约50~61小时
培养基和添加剂	RPMI-1640（中乔新舟 货号：ZQ-200）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）+1% Sodium Pyruvate 100 mM Solution（中乔新舟  货号：CSP003）
推荐完全培养基货号	ZM0367
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 12 D13S317: 13 D16S539: 13,14 D5S818: 12 D7S820: 9,10 TH01: 6 TPOX: 11 vWA: 16,17
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达
基因表达
保藏机构	ATCC; CRL-2336 DSMZ; ACC-513
供应限制	仅供科研使用

货号	ZQ0367
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer
DOI： 10.7150/ijbs.39063
发表时间： 2019-11-08
期刊： International Journal of Biological Sciences
影响因子： 4.067
货号： ZQ0367
产品名称： HCC1937 cells

原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909971/

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