产品名称	HCC1937人乳腺癌细胞
货号	ZQ0367
产品介绍	HCC1937是一种来源于成年女性原发肿瘤的人乳腺癌细胞系。该细胞系表现出侵袭性乳腺癌表型特征的几种遗传改变，包括BRCA1基因的纯合突变(5382C突变)，这是乳腺癌易感性的显著标志。这种突变的存在与乳腺癌的家族模式一致，因为它也在其他家庭成员中检测到，表明恶性肿瘤的遗传方面。此外，HCC1937在TP53基因中有一个获得性突变，加上野生型等位基因的缺失，进一步加剧了其肿瘤抑制基因的缺陷。 该细胞系还显示PTEN基因的纯合缺失，并且在涉及癌症发病的多个位点上显示杂合性缺失，这表明复杂的遗传背景有利于致癌转化。从表型角度来看，HCC1937不表达雌激素受体(ER)或孕激素受体(PR)，将其分为ER阴性和PR阴性，这是更侵袭性疾病病程的典型标志。此外，该细胞不表达Her2-neu和p53，但上皮糖蛋白2 (EGP2)和细胞角蛋白19呈阳性，这表明它们的上皮来源和恶性性质。特殊的标记谱和基因组成使HCC1937成为研究乳腺癌分子机制和检测类似侵袭性乳腺癌靶向治疗的有价值的模型。 注意事项： HCC1937细胞难消化且生长较慢，该细胞形态不均一呈不规则形状，有一些含有液泡的巨大细胞，该细胞胞体有黑色颗粒物，且分泌少量黑点属正常现象。细胞密度过高会有圆细胞漂浮是正常现象
种属	人
性别/年龄	女/23岁
组织	乳腺；乳房/导管
疾病	TNM IIB分期，3级，原发性导管癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁（线状生长为大的上皮细胞，倾向于以高细胞密度漂浮）
倍增时间	大约50~61小时
培养基和添加剂	RPMI-1640（中乔新舟 货号：ZQ-200）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）+1% Sodium Pyruvate 100 mM Solution（中乔新舟  货号：CSP003）
推荐完全培养基货号	ZM0367
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 12 D13S317: 13 D16S539: 13,14 D5S818: 12 D7S820: 9,10 TH01: 6 TPOX: 11 vWA: 16,17
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-2336 DSMZ; ACC-513
供应限制	仅供科研使用

货号	ZQ0367
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Macrophage Colony-stimulating Factor Mediates the Recruitment of Macrophages in Triple negative Breast Cancer
DOI： 10.7150/ijbs.39063
发表时间： 2019-11-08
期刊： International Journal of Biological Sciences
影响因子： 4.067
货号： ZQ0367
产品名称： HCC1937 cells

原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909971/

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