产品名称	Hs 578T人乳腺癌细胞
货号	ZQ0372
产品介绍	hs578t细胞系是一种来源于乳腺癌的人乳腺癌细胞系，它与正常成纤维细胞样细胞株Hs 578Bst起源于同一位患者。 Hs 578T细胞株最初是多角形的，但在传代过程中选择并克隆了星形的细胞形态。 电镜下观察到酪蛋白颗粒聚集，桥粒，紧密连接，脂质体和光滑内质网小泡。该细胞表现出上皮样形态，并以贴壁生长模式为特征。Hs 578T细胞系被广泛用于癌症研究，特别是研究乳腺癌的进展和转移机制。该细胞显示出TP53基因的突变，这是一种关键的肿瘤抑制基因，这种突变通常与某些癌症类型的侵袭性行为有关。 Hs 578T细胞是激素受体阴性的，这意味着它不表达雌激素或孕激素受体，这将它归类为三阴性乳腺癌细胞。这使得它在针对这种侵袭性乳腺癌亚型的治疗研究中特别有价值，与激素受体阳性乳腺癌相比，这种亚型的治疗选择通常较少，预后也较差。研究人员利用Hs 578T细胞系探索肿瘤生物学的各个方面，包括细胞增殖、迁移以及对化疗和靶向治疗的反应。 hs 578t细胞系也表达vimentin，这是一种与上皮-间质转化(EMT)相关的标志物，EMT在癌症转移中起着至关重要的作用。涉及这些细胞的研究有助于阐明参与EMT的分子途径，并为抑制癌症扩散的潜在治疗靶点提供见解。此外，Hs 578T细胞已被用于药物筛选试验，以鉴定具有潜在抗癌活性的化合物。 注意事项： HS 578T细胞胞体有黑点以及在细胞生长过程中会分泌黑点，属正常现象。
种属	人
性别/年龄	女/74岁
组织	乳腺/乳房
疾病	癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约32.35~53.8小时
培养基和添加剂	DMEM高糖（品牌：中乔新舟 货号：ZQ-100）+10%胎牛血清（中乔新舟 货号：ZQ0500）+1%P/S（中乔新舟  货号：CSP006）+0.01mg/mL牛胰岛素（中乔新舟 货号：CSP021）
推荐完全培养基货号	ZM0372
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 13 D13S317: 11 D16S539: 9,12 D5S818: 11 D7S820: 10 TH01: 9,9.3 TPOX: 8 vWA: 17
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; CRL-7849 ATCC; HTB-126 BCRC; 60120 DSMZ; ACC-781 ECACC; 86082104
供应限制	仅供科研使用

货号	ZQ0372
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题： Development of a Prognostic Model Based on the Identification of EMT-Related lncRNAs in Triple-Negative Breast Cancer
DOI： 10.1155/2021/9219961
发表时间： 2021-11-27
期刊： Journal of Oncology
影响因子： 4.375
货号： ZQ0372
产品名称： Hs 578T cell

原文链接： https://www.hindawi.com/journals/jo/2021/9219961/

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