配套完培,组合使用,省时省力!
产品名称
MDA-MB-231人乳腺癌细胞
货号
ZQ0118
产品介绍
MDA-MB-231是一种人乳腺癌细胞系,最初从一位51岁白人女性患者的转移性乳腺腺癌胸水中分离得到。这种细胞系具有上皮细胞样的形态,并表现出贴壁生长的特性。在裸鼠和ALS处理的BALB/c小鼠中,该细胞能形成低分化腺癌(III级)。该细胞表达表皮生长因子EGF受体、TGF-α受体和WNT7B癌基因。该细胞株为三阴性乳腺癌细胞(ER−、PR−、HER2−),可作为合适的转染宿主,广泛用于乳腺癌等疾病研究。据报道常用乳腺癌的生物学特性、药物筛选和疗效评估、转移和侵袭机制、肿瘤微环境和免疫反应的研究。
【注意事项】
1. 该细胞若使用的L-15基础培养液由磷酸盐和游离碱氨基酸代替了碳酸氢钠缓冲体系。 该培养基必须在没有CO2平衡的环境中培养细胞。不能在普通的5% CO2细胞培养箱中培养,培养液颜色会明显变黄。
2. 细胞形态大部分为纺锤状,也有部分细胞呈圆形,存在少量悬浮细胞。
3. 如果发现细胞生长过于缓慢,可将胎牛血清浓度提高至20%。
种属
人
性别/年龄
女/51岁
组织
乳腺腺癌,转移性胸膜渗出液
疾病
乳腺腺癌(NCIt:C5214)
生物安全等级
BSL-1
STR位点信息
Amelogenin: X
CSF1PO: 12,13
D13S317: 13
D16S539: 12
D5S818: 12
D7S820: 8,9
TH01: 7,9.3
TPOX: 8,9
vWA: 15,18
细胞类型
肿瘤细胞
形态学
上皮细胞
生长方式
贴壁生长
倍增时间
大约24.7~41.9小时
培养基和添加剂(默认)
DMEM (中乔新舟 货号:ZQ-100)+10%胎牛血清(中乔新舟 货号:ZQ500-A)+1%双抗(中乔新舟 货号:CSP006)
注意默认方案培养条件: 气相:空气,95%;CO2,5%, 温度:37℃
培养方案B(可选)
L-15(中乔新舟 货号:ZQ-1100)+10%FBS(中乔新舟 货号:ZQ500-A)+1%PS(中乔新舟 货号:CSP006)
注意B方案培养条件: 气相:空气,100%;温度:37℃
推荐完全培养基货号
B方案完全培养基货号
培养条件(默认)
37℃;95%空气,5%二氧化碳
抗原表达/受体表达
***
基因表达
***
保藏机构
ATCC、ECACC、DSMZ、
供应限制
仅供科研使用
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1、Amino-Functionalized Zirconium-Based Metal–Organic Frameworks as Bifunctional Nanomaterials to Treat Bone Tumors and Promote Osteogenesis.(2023-11-09)
作者:Jongpeng Yuan,Xujie Liu
期刊:ACS Applied Materials & Interfaces
DOI: 10.1021/acsami.3c11787
影响因子 :9.5
引用产品:MC3T3-E1, MNNG/HOS and MDA-MB-231 cell
https://pubs.acs.org/doi/full/10.1021/acsami.3c11787
2、Chitosan/NH2-MIL-125 (Ti) scaffold loaded with doxorubicin for postoperative bone tumor clearance and osteogenesis: An in vitro study.( Pub Date : 2024-2-23)
作者:Yaoxun Zeng , Jiongpeng Yuan
期刊:International Journal of Biological Macromolecules
DOI: DOI:10.1016/j.ijbiomac.2024.130368
影响因子 :8.2
引用产品: (MC3T3-E1 cells, ZQ0095),(RAW264.7 cells, ZQ0098),(MDA-MB-231 cells, ZQ0118),(HUVEC cells, ZQY004)
https://www.sciencedirect.com/science/article/pii/S0141813024011711?via%3Dihub
3、论文标题: Prognostic value of gamma-interferon-inducible lysosomal thiol reductase expression in female patients diagnosed with breast cancer
DOI: 10.1002/ijc.33843
发表时间: 2021-10-25
期刊: INTERNATIONAL JOURNAL OF CANCER
影响因子: 7.396
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.33843
4、论文标题: LncRNA SNHG6/miR-125b-5p/BMPR1B Axis: A New Therapeutic Target for Triple-Negative Breast Cancer
DOI: 10.3389/fonc.2021.678474
发表时间: 2021-05-07
期刊: Frontiers in Oncology
影响因子: 6.244
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://www.frontiersin.org/articles/10.3389/fonc.2021.678474/full
5、论文标题: The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis
DOI: 10.1186/s12935-021-02113-5
发表时间: 2021-08-21
期刊: Cancer Cell International
影响因子: 5.722
货号: ZQ0118
产品名称: MDA-MB-231 cell
原文链接: https://link.springer.com/article/10.1186/s12935-021-02113-5
6、论文标题: Long non-coding RNA ROR recruits histone transmethylase MLL1 to up-regulate TIMP3 expression and promote breast cancer progression
DOI: 10.1186/s12967-020-02682-5
发表时间: 2021-03-02
期刊: Journal of Translational Medicine
影响因子: 5.531
货号: ZQ0118
产品名称: MDA-MB-231 cell
原文链接: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-020-02682-5
7、论文标题: MMP-2 sensitive poly(malic acid) micelles stabilized by π–π stacking enable high drug loading capacity
DOI: 10.1039/D0TB01682A
发表时间: 2020-08-11
期刊: Journal of Materials Chemistry B
影响因子: 5.344
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://pubs.rsc.org/en/content/articlelanding/2020/tb/d0tb01682a
8、论文标题: T-17, a novel cyclin-dependent kinases/histone deacetylases dual inhibitor, induces cancer cells death through cell cycle arrest and apoptosis
DOI: 10.1002/ddr.21977
发表时间: 2022-07-17
期刊: DRUG DEVELOPMENT RESEARCH
影响因子: 5.004
货号: ZQ0118
产品名称: MDA-MB-231 cell
原文链接: https://onlinelibrary.wiley.com/doi/abs/10.1002/ddr.21977
9、论文标题: Development of a Prognostic Model Based on the Identification of EMT-Related lncRNAs in Triple-Negative Breast Cancer
DOI: 10.1155/2021/9219961
发表时间: 2021-11-27
期刊: Journal of Oncology
影响因子: 4.375
货号: ZQ0118
产品名称: MDA-MB-231 cell
原文链接: https://www.hindawi.com/journals/jo/2021/9219961/
10、论文标题: METTL14 promotes the migration and invasion of breast cancer cells by modulating N6‑methyladenosine and hsa‑miR‑146a‑5p expression
DOI: 10.3892/or.2020.7515
发表时间: 2020-02-24
期刊: ONCOLOGY REPORTS
影响因子: 3.417
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://www.spandidos-publications.com/10.3892/or.2020.7515
11、论文标题: SYK-targeted dendritic cell-mediated cytotoxic T lymphocytes enhance the effect of immunotherapy on retinoblastoma
DOI: 10.1007/s00432-018-2584-x
发表时间: 2018-01-25
期刊: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
影响因子: 3.282
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://link.springer.com/article/10.1007/s00432-018-2584-x
12、论文标题: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling
DOI: 10.1007/s11010-018-3281-4
发表时间: 2018-01-31
期刊: MOLECULAR AND CELLULAR BIOCHEMISTRY
影响因子: 2.561
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://link.springer.com/article/10.1007/s11010-018-3281-4
13、论文标题: Long Non-Coding RNA A2M-AS1 Promotes Breast Cancer Progression by Sponging microRNA-146b to Upregulate MUC19
DOI: 10.2147/IJGM.S278564
发表时间: 2020-11-27
期刊: International Journal of General Medicine
影响因子: 1.927
货号: ZQ0118
产品名称: MDA-MB-231 cells
原文链接: https://www.ncbi.nlm.nih.gov/pmc/articles/pmc7708314/
14、PubMed=27331101; DOI=10.1016/j.dib.2016.05.040
Aumsuwan P., Khan S.I., Khan I.A., Walker L.A., Dasmahapatra A.K.
Gene expression profiling and pathway analysis data in MCF-7 and MDA-MB-231 human breast cancer cell lines treated with dioscin.
Data Brief 8:272-279(2016)
15、PubMed=27377824; DOI=10.1038/sdata.2016.52
Mestdagh P., Lefever S., Volders P.-J., Derveaux S., Hellemans J., Vandesompele J.
Long non-coding RNA expression profiling in the NCI60 cancer cell line panel using high-throughput RT-qPCR.
Sci. Data 3:160052-160052(2016)
16、PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)
17、PubMed=27807467; DOI=10.1186/s13100-016-0078-4
Zampella J.G., Rodic N., Yang W.R., Huang C.R.L., Welch J., Gnanakkan V.P., Cornish T.C., Boeke J.D., Burns K.H.
A map of mobile DNA insertions in the NCI-60 human cancer cell panel.
Mob. DNA 7:20.1-20.11(2016)
18、PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)
19、PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470
Yen T.-Y., Bowen S., Yen R., Piryatinska A., Macher B.A., Timpe L.C.
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)
20、PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Saunus J.M., Smart C.E., Kutasovic J.R., Johnston R.L., Kalita-de Croft P., Miranda M., Rozali E.N., Vargas A.C., Reid L.E., Lorsy E., Cocciardi S., Seidens T., McCart Reed A.E., Dalley A.J., Wockner L.F., Johnson J., Sarkar D., Askarian-Amiri M.E., Simpson P.T., Khanna K.K., Chenevix-Trench G., Al-Ejeh F., Lakhani S.R.
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)
21、PubMed=29273624; DOI=10.1101/gr.226019.117
Franco H.L., Nagari A., Malladi V.S., Li W.-Q., Xi Y.-X., Richardson D., Allton K.L., Tanaka K., Li J., Murakami S., Keyomarsi K., Bedford M.T., Shi X.-B., Li W., Barton M.C., Dent S.Y.R., Kraus W.L.
Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.
Genome Res. 28:159-170(2018)
22、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)
23、PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)
24、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)
25、PubMed=31092827; DOI=10.1038/s41467-019-10148-6
Liu K., Newbury P.A., Glicksberg B.S., Zeng W.Z.-D., Paithankar S., Andrechek E.R., Chen B.
Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data.
Nat. Commun. 10:2138.1-2138.12(2019)
26、PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)
27、PubMed=32782317; DOI=10.1038/s41598-020-70393-4
Risha Y., Minic Z., Ghobadloo S.M., Berezovski M.V.
The proteomic analysis of breast cell line exosomes reveals disease patterns and potential biomarkers.
Sci. Rep. 10:13572-13572(2020)
28、PubMed=34238275; DOI=10.1186/s12885-021-08511-2
Samson J., Derlipanska M., Zaheed O., Dean K.
Molecular and cellular characterization of two patient-derived ductal carcinoma in situ (DCIS) cell lines, ETCC-006 and ETCC-010.
BMC Cancer 21:790.1-790.20(2021)
29、PubMed=34320349; DOI=10.1016/j.celrep.2021.109441
Jochems F., Thijssen B., De Conti G., Jansen R., Pogacar Z., Groot K., Wang L.-Q., Schepers A., Wang C., Jin H.-J., Beijersbergen R.L., Leite de Oliveira R., Wessels L.F.A., Bernards R.
The cancer SENESCopedia: a delineation of cancer cell senescence.
Cell Rep. 36:109441.1-109441.22(2021)
30、PubMed=35042871; DOI=10.1038/s41523-021-00379-6
Rypens C., Bertucci F., Finetti P., Robertson F.M., Fernandez S.V., Ueno N.T., Woodward W.A., Van Golen K., Vermeulen P., Dirix L., Viens P., Birnbaum D., Devi G.R., Cristofanilli M., Van Laere S.
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC.
NPJ Breast Cancer 8:12.1-12.12(2022)
31、PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)
产品名称 | 价格 | 指令 |
MCF-7人乳腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
MDA-MB-453人乳腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
ZR-75-1人乳腺癌细胞(STR鉴定) | ¥1600.00 | 购物车 》 |
SHZ-88大鼠乳腺癌细胞(种属鉴定) | ¥1000.00 | 购物车 》 |
人乳腺癌细胞BcaP-37(hela污染,暂不供应) | ¥1200.00 | 购物车 》 |
4T1小鼠乳腺癌细胞(种属鉴定)[套餐促销] | ¥1350.00 | 购物车 》 |
ZR-75-30人乳腺癌细胞 | ¥1800.00 | 购物车 》 |
HCC1937人乳腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
Hs 578T人乳腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
MDA-MB-468人乳腺癌细胞(STR鉴定) | ¥1350.00 | 购物车 》 |
支原体检测试剂盒 | ¥800.00 | 购物车 》 |
支原体清除试剂盒 | ¥600.00 | 购物车 》 |
国产转染试剂 | ¥800.00 | 购物车 》 |
优级胎牛血清 | ¥2580(开学促销) | 购物车 》 |
L-15 基础培养基 | ¥158.00 | 购物车 》 |
L-15 完全培养基 | ¥350.00 | 购物车 》 |