产品名称	HT-29人结肠癌细胞
货号	ZQ0057
产品介绍	HT-29是一种人结肠腺癌细胞系，最初是在1964年从一位44岁女性结直肠癌患者的原发肿瘤中分离出来建立的。这些细胞具有上皮细胞的形态特征，在体外培养时贴壁生长，并且表现出成熟肠细胞的一些特性。是结直肠癌研究的重要工具，通过结合多种研究方法和技术，科学家们可以进一步揭示结直肠癌的生物学机制，并开发出更有效的治疗策略。该细胞表达尿激酶受体，但未检测到纤溶酶原激活物活性[PubMed ID:8381394]。CD4表达阴性，但细胞表面表达半乳糖神经酰胺（一个HIV的可替代受体）。另致癌基因c-myc、K-ras、H-ras、N-ras、Myb、sis、fos表达阳性，过量产生p53抗原，在p53基因的273密码子处有G->A突变导致Arg->His替换，未检测到致癌基因N-myc的表达。 【注意事项】 HT-29复苏后第一周可能会有大量漂浮细胞，可更换新鲜培养液，同时将漂浮的细胞离心收集后加回到培养瓶中与贴壁细胞共同培养。新复苏的细胞会以补丁形态三维接触生长（即不是单层扁平生长），待细胞分裂生长后将会变回上皮细胞形态单层扁平生长。
种属	人
性别/年龄	女/44岁
组织	结肠
疾病	结肠直肠腺癌
生物安全等级	BSL-1
STR位点信息	Amelogenin: X CSF1PO: 11,12 D13S317: 11,12 D16S539: 11,12 D5S818: 11,12 D7S820: 10 TH01: 6,9 TPOX: 8,9 vWA: 17,19 D3S1358: 15,17 D21S11: 29,30 D18S51: 13 Penta_E: 14,16 Penta_D: 11,13 D8S1179: 10,16 FGA: 20,22 D19S433: 14 D2S1338: 19,23
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约36.93~60小时
培养基和添加剂	McCoy's 5A基础培养基（品牌：中乔新舟 货号：ZQ-1000）+10%FBS（品牌：中乔新舟  货号：ZQ0500）+1%PS（货号：CSP006）
推荐完全培养基货号	ZM0057
培养条件	95%空气，5%二氧化碳；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC; HTB-38 BCRJ; 0111 CCLV; CCLV-RIE 0960 DSMZ; ACC-299 ECACC; 91072201
供应限制	仅供科研使用

货号	ZQ0057
发货规格	活细胞：T25培养瓶*1瓶或者1ml 冻存管*1支（细胞量约为5 x 10^5 cells/vial）二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

1、论文标题： MiR-21-5p Induces Pyroptosis in Colorectal Cancer via TGFBI

DOI： 10.3389/fonc.2020.610545
发表时间： 2021-02-05
期刊： Frontiers in Oncology
影响因子： 6.244
货号： ZQ0057
产品名称： HT-29 cells
原文链接： https://pubmed.ncbi.nlm.nih.gov/33614494/

2、论文标题： Knockdown of SFRS9 Inhibits Progression of Colorectal Cancer Through Triggering Ferroptosis Mediated by GPX4 Reduction
DOI： 10.3389/fonc.2021.683589
发表时间： 2021-07-16
期刊： Frontiers in Oncology
影响因子： 6.244
货号： ZQ0057
产品名称： HT29 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8322952/

3、论文标题： Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer
DOI： 10.1016/j.phymed.2021.153881
发表时间： 2021-12-09
期刊： PHYTOMEDICINE
影响因子： 5.34
货号： ZQ0057
产品名称： HT29 cells

原文链接： https://www.sciencedirect.com/science/article/pii/S0944711321004219

4、论文标题： PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells
DOI： 10.18632/aging.103690
发表时间： 2020-07-20
期刊： Aging-US
影响因子： 4.831
货号： ZQ0057
产品名称： HT29 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485722/

5、论文标题： Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using 99mTc-MAG3-Cet-F(ab)2-Based SPECT/CT Imaging
DOI： 10.1155/2022/3748315
发表时间： 2022-06-24
期刊： Molecular Imaging
影响因子： 4.488
货号： ZQ0057
产品名称： HT29 cells
原文链接： https://www.hindawi.com/journals/moi/2022/3748315/

6、论文标题： miR-524-5p inhibits angiogenesis through targeting WNK1 in colon cancer cells
DOI： 10.1152/ajpgi.00369.2019
发表时间： 2020-04-07
期刊： AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
影响因子： 3.725
货号： ZQ0057
产品名称： HT-29 cells
原文链接： https://journals.physiology.org/doi/abs/10.1152/ajpgi.00369.2019

7、论文标题： Genes encoding bile salt hydrolase differentially affect adhesion of Lactiplantibacillus plantarum AR113
DOI： 10.1002/jsfa.11487
发表时间： 2021-08-31
期刊： JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
影响因子： 3.639
货号： ZQ0057
产品名称： HT29 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1002/jsfa.11487

8、论文标题： Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation
DOI： 10.3892/or.2020.7495
发表时间： 2020-02-10
期刊： ONCOLOGY REPORTS
影响因子： 3.417
货号： ZQ0057
产品名称： HT-29 cells
原文链接： https://www.spandidos-publications.com/10.3892/or.2020.7495

9、论文标题： LINC01198 promotes colorectal cancer cell proliferation and inhibits apoptosis via Notch signaling pathway.
DOI： 10.26355/eurrev_202008_22641
发表时间： 2020-08-01
期刊： European Review for Medical and Pharmacological Sciences
影响因子： 3.024
货号： ZQ0057
产品名称： HT-29 cells
原文链接： https://europepmc.org/article/med/32894550?javascript_support=no

10、论文标题： Preparing Sodium Alginate/Polyethyleneimine Spheres for Potential Application of Killing Tumor Cells by Reducing the Concentration of Copper Ions in the Lesions of Colon Cancer
DOI： 10.3390/ma12091570
发表时间： 2019-05-13
期刊： Materials
影响因子： 2.972
货号： ZQ0057
产品名称： HT-29 cells
原文链接： https://www.mdpi.com/461434

11、论文标题： Engineering NK-92 Cell by Upregulating CXCR2 and IL-2 Via CRISPR-Cas9 Improves Its Antitumor Effects as Cellular Immunotherapy for Human Colon Cancer
DOI： 10.1089/jir.2021.0078
发表时间： 2021-12-15
期刊： JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
影响因子： 2.607
货号： ZQ0057
产品名称： HT29 cells
原文链接： https://www.liebertpub.com/doi/abs/10.1089/jir.2021.0078

12、论文标题： Down-regulation of lncRNA DNAJC3-AS1 inhibits colon cancer via regulating miR-214-3p/LIVIN axis
DOI： 10.1080/21655979.2020.1757224
发表时间： 2020-04-30
期刊： Bioengineered
影响因子： 2.205
货号： ZQ0057
产品名称： HT29 cells

原文链接： https://www.tandfonline.com/doi/abs/10.1080/21655979.2020.1757224

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