产品名称	SW480人结肠癌细胞
货号	ZQ0063
产品介绍	SW480是一种人结肠腺癌细胞系，SW480和SW620均源自同一位男性患者，其中SW480是原发性结肠腺癌。最初是从一位50岁白人男性患者的直肠腺癌组织中分离得到的。这个细胞系在癌症研究中非常有用，尤其是在研究结直肠癌的生物学行为和药物反应方面。该细胞的CSAp和结肠抗原3阴性，角蛋白免疫过氧化物酶染色阳性。该细胞的p53基因第273位密码子的G->A突变导致Arg->His替代，第309位密码子的C->T突变导致Pro->Ser替代。该细胞p53蛋白表达水平升高，癌基因c-myc、K-ras、H-ras、N-ras、myb、sis和fos的表达呈阳性，但未检测到癌基因N-myc的表达。此外，该细胞不表达细胞基质裂解酶Matrilysin（一种与肿瘤入侵相关的金属蛋白酶）。有报道称该细胞表达GM-CSF。此外，该细胞K-RAS蛋白第12位氨基酸Gly突变为Val（c.35G>T），常被用于PCR检测该位点突变的阳性对照。该细胞是研究结直肠癌的重要工具，为科学家们提供了一个模型系统，用于研究疾病的进展和开发新的治疗方法。 注意事项： 1.该细胞使用的L-15基础培养液由磷酸盐和游离碱氨基酸代替了碳酸氢钠缓冲体系。该培养基必须在没有二氧化碳平衡的环境中培养细胞,不能在普通的5%二氧化碳细胞培养箱中培养,否则培养液颜色会明显变黄。
种属	人
性别/年龄	男/50岁
组织	结肠
疾病	杜克斯氏B型,结肠直肠腺癌
细胞类型	肿瘤细胞
形态学	上皮
生长方式	贴壁
倍增时间	大约24~50小时
培养基和添加剂	L15基础培养基（中乔新舟 货号：ZQ-1100）+10%胎牛血清（中乔新舟 货号：ZQ500-A)+1%P/S(中乔新舟货号:CSP006）
推荐完全培养基货号	ZM0063
生物安全等级	BSL-1
力量值位点信息	Amelogenin: X CSF1PO: 13,14 D13S317: 12 D16S539: 13 D5S818: 13 D7S820: 8 TH01: 8 TPOX: 11 vWA: 16 Penta_D: 9,15 Penta_E: 10 D3S1358: 15 D21S11: 30,30.2 D8S1179: 13 FGA: 24 D19S433: 13 D2S1338: 17,24 D18S51: 13
培养条件	100%空气；37℃
抗原表达/受体表达	***
基因表达	***
保藏机构	ATCC；DSMZ CCL-228；ECACC ACC-313；87092801
供应限制	仅供科研使用

货号	ZQ0063
发货规格	活细胞:T25培养瓶*1瓶或者1毫升冻存管*1支（细胞量约为5个10^5细胞/瓶)二选一
发货形式	活细胞：常温运输；冻存管：干冰运输
储存温度	活细胞：培养箱；冻存管：液氮罐
产地	中国
供应限制	仅供科研使用

论文标题microRNA-96通过调节AMPKα2-FTO-m6A/MYC轴促进结直肠癌的发生和发展
DOI: 10.1186/s13046-020-01731-7
发表时间: 2020-11-12
期刊:实验和临床癌症研究杂志
影响因子: 7.068
货号:ZQ0063
产品名称:SW480细胞
原文链接：https://link . springer . com/article/10.1186/s 13046-020-01731-7

论文标题： Knockdown of SFRS9 Inhibits Progression of Colorectal Cancer Through Triggering Ferroptosis Mediated by GPX4 Reduction
DOI： 10.3389/fonc.2021.683589
发表时间： 2021-07-16
期刊： Frontiers in Oncology
影响因子： 6.244
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/pmc8322952/

论文标题： Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer
DOI： 10.1016/j.phymed.2021.153881
发表时间： 2021-12-09
期刊： PHYTOMEDICINE
影响因子： 5.34
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0944711321004219

论文标题： Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO-mediated MZF1/c-Myc axis
DOI： 10.1111/jcmm.16291
发表时间： 2021-02-02
期刊： JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
影响因子： 5.31
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://onlinelibrary.wiley.com/doi/abs/10.1111/jcmm.16291

论文标题： The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism
DOI： 10.1007/s00432-020-03179-w
发表时间： 2020-03-09
期刊： JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
影响因子： 3.656
货号： ZQ0063
产品名称： SW-480 cells
原文链接： https://link.springer.com/article/10.1007/s00432-020-03179-w 论文标题： MiR-346-5p promotes colorectal cancer cell proliferation in vitro and in vivo by targeting FBXL2 and activating the β-catenin signaling pathway
DOI： 10.1016/j.lfs.2020.117300
发表时间： 2020-01-14
期刊： LIFE SCIENCES
影响因子： 3.647
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.sciencedirect.com/science/article/pii/S0024320520300473

论文标题： Sulforaphane suppresses carcinogenesis of colorectal cancer through the ERK/Nrf2‑UDP glucuronosyltransferase 1A metabolic axis activation
DOI： 10.3892/or.2020.7495
发表时间： 2020-02-10
期刊： ONCOLOGY REPORTS
影响因子： 3.417
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.spandidos-publications.com/10.3892/or.2020.7495

论文标题： Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway
DOI： 10.1155/2022/7132159
发表时间： 2022-05-18
期刊： Biomed Research International
影响因子： 3.411
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.hindawi.com/journals/bmri/2022/7132159/

论文标题： LINC01198 promotes colorectal cancer cell proliferation and inhibits apoptosis via Notch signaling pathway.
DOI： 10.26355/eurrev_202008_22641
发表时间： 2020-08-01
期刊： European Review for Medical and Pharmacological Sciences
影响因子： 3.024
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://europepmc.org/article/med/32894550?javascript_support=no

论文标题： miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα
DOI： 10.1186/s12885-018-5245-1
发表时间： 2019-01-08
期刊： BMC CANCER
影响因子： 2.933
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://link.springer.com/article/10.1186/s12885-018-5245-1

论文标题： Evodiamine inhibits vasculogenic mimicry in HCT116 cells by suppressing hypoxia-inducible factor 1-alpha-mediated angiogenesis
DOI： 10.1097/CAD.0000000000001030
发表时间： 2021-01-08
期刊： ANTI-CANCER DRUGS
影响因子： 2.248
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861498/

论文标题： Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial–mesenchymal transition
DOI： 10.1007/s10529-020-02923-z
发表时间： 2020-06-04
期刊： BIOTECHNOLOGY LETTERS
影响因子： 1.977
货号： ZQ0063
产品名称： SW480 cells
原文链接： https://link.springer.com/content/pdf/10.1007/s10529-020-02923-z.pdf

论文标题： Two new compounds from Carpesium abrotanoides
DOI： 10.1016/j.phytol.2020.08.012
发表时间： 2020-09-17
期刊： Phytochemistry Letters
影响因子： 1.459
货号： ZQ0063
产品名称： SW480 cells

原文链接： https://www.sciencedirect.com/science/article/pii/S187439002030639X

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