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LOVO人结肠癌细胞(STR鉴定)
英文名:LOVO
货号:ZQ0058
价格:¥1400.00
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LOVO人结肠癌细胞(STR鉴定)

¥1400.00
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LoVo人结肠癌细胞专用培养基

¥350.00 ¥500.00

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¥1750 ¥1900.00
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  • 产品说明
  • 产品规格
  • 参考文献
  • STR鉴定

产品名称

LOVO人结肠癌细胞

货号

ZQ0058

产品介绍

LoVo人结肠癌细胞是一种从人类结直肠癌组织中分离并培养得到的癌细胞系。这种细胞系最初是1971年从患有IV级Dukes C结肠直肠癌的56岁白人男性患者左锁骨上区转移性肿瘤结节的碎片。该细胞系在癌症研究中非常有用,因为它们保留了原始肿瘤的许多特征,在癌症、毒理学和免疫学研究中应用广泛。可以用来测试新的药物疗法,研究癌症的生物学行为,以及理解癌症的分子机制。此外,也常用于转染实验,用于研究基因功能和信号传导途径。该细胞的CSAp和结肠抗原3(colon antigen 3)表达阴性。肿瘤基因c-myc、K-ras、H-ras、 N-ras、Myb, sis和fos表达阳性,但未检测到 N-myc表达。该细胞表达肿瘤特定的核基质蛋白CC-3和CC-4,可在裸鼠体中成瘤。

注意事项:LoVo细胞呈团块状生长,复苏或传代后贴壁慢,请传代后48小时再进行换液等后续操作。细胞密度在80%即可传代。

种属

性别/年龄

男/56岁

组织

结肠;分离自转移灶:左锁骨上区域

疾病

杜克斯氏丙型,四级,结肠直肠腺癌

细胞类型

肿瘤细胞 

形态学

上皮样

生长方式

贴壁

倍增时间

大约33~52小时 

培养基和添加剂

F12K基础培养基(中乔新舟  货号: ZQ-599)+10%胎牛血清(中乔新舟  货号:ZQ500-A)+1%P/S(中乔新舟 货号:CSP006

推荐完全培养基货号

ZM0058

生物安全等级

BSL-1

STR位点信息

Amelogenin: X,Y
CSF1PO: 11,13,14
D13S317: 8,11
D16S539: 9,12
D5S818: 11,12,13
D7S820: 9.3,10,11
TH01: 9.3
TPOX: 8,9
vWA: 17,18
D3S1358: 14,15,16,17
D21S11: 29,31.2
D18S51: 13,18
Penta_D: 10,14
Penta_E: 10,16
FGA: 18,20
D8S1179: 10
D19S433: 14,15
D2S1338: 17,18

培养条件

95%空气,5%二氧化碳;37℃

抗原表达/受体表达

***  

基因表达

***  

保藏机构

ATCC; CCL-229 BCRC; 60148 BCRJ; 0332 CCLV; CCLV-RIE 1151 DSMZ; ACC-350 ECACC; 87060101

供应限制

仅供科研使用

货号

ZQ0058

发货规格

活细胞:T25培养瓶*1瓶或者1ml 冻存管*1支(细胞量约为5 x 10^5 cells/vial)二选一

发货形式

活细胞:常温运输;冻存管:干冰运输

储存温度

活细胞:培养箱;冻存管:液氮罐

产地

中国

供应限制

仅供科研使用


1、论文标题: Inhibition of SRSF9 enhances the sensitivity of colorectal cancer to erastin-induced ferroptosis by reducing glutathione peroxidase 4 expression
DOI: 10.1016/j.biocel.2021.105948
发表时间: 2021-02-17
期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
影响因子: 5.085
货号: ZQ0058
产品名称: LOVO cells
原文链接: https://www.sciencedirect.com/science/article/pii/S1357272521000327
 

2、论文标题: LINC01198 promotes colorectal cancer cell proliferation and inhibits apoptosis via Notch signaling pathway.
DOI: 10.26355/eurrev_202008_22641
发表时间: 2020-08-01
期刊: European Review for Medical and Pharmacological Sciences
影响因子: 3.024
货号: ZQ0058
产品名称: LOVO cells
原文链接: https://europepmc.org/article/med/32894550?javascript_support=no


3、 论文标题: P16 promotes the growth and mobility potential of breast cancer both in vitro and in vivo: the key role of the activation of IL-6/JAK2/STAT3 signaling
DOI: 10.1007/s11010-018-3281-4
发表时间: 2018-01-31
期刊: MOLECULAR AND CELLULAR BIOCHEMISTRY
影响因子: 2.561
货号: ZQ0058
产品名称: LOVO cells
原文链接: https://link.springer.com/article/10.1007/s11010-018-3281-4


4、PubMed=26537799; DOI=10.1074/mcp.M115.051235

Holst S., Deuss A.J.M., van Pelt G.W., van Vliet S.J., Garcia-Vallejo J.J., Koeleman C.A.M., Deelder A.M., Mesker W.E., Tollenaar R.A.E.M., Rombouts Y., Wuhrer M.
N-glycosylation profiling of colorectal cancer cell lines reveals association of fucosylation with differentiation and caudal type homebox 1 (CDX1)/villin mRNA expression.
Mol. Cell. Proteomics 15:124-140(2016)


5、PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)


6、PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)


7、PubMed=28683746; DOI=10.1186/s12943-017-0691-y
Berg K.C.G., Eide P.W., Eilertsen I.A., Johannessen B., Bruun J., Danielsen S.A., Bjornslett M., Meza-Zepeda L.A., Eknaes M., Lind G.E., Myklebost O., Skotheim R.I., Sveen A., Lothe R.A.
Multi-omics of 34 colorectal cancer cell lines -- a resource for biomedical studies.
Mol. Cancer 16:116.1-116.16(2017)


8、PubMed=28854368; DOI=10.1016/j.celrep.2017.08.010
Roumeliotis T.I., Williams S.P., Goncalves E., Alsinet C., Del Castillo Velasco-Herrera M., Aben N., Ghavidel F.Z., Michaut M., Schubert M., Price S., Wright J.C., Yu L., Yang M., Dienstmann R., Guinney J., Beltrao P., Brazma A., Pardo M., Stegle O., Adams D.J., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Choudhary J.S.
Genomic determinants of protein abundance variation in colorectal cancer cells.
Cell Rep. 20:2201-2214(2017)


9、PubMed=29101300; DOI=10.15252/msb.20177701
Frejno M., Zenezini Chiozzi R., Wilhelm M., Koch H., Zheng R.-S., Klaeger S., Ruprecht B., Meng C., Kramer K., Jarzab A., Heinzlmeir S., Johnstone E., Domingo E., Kerr D., Jesinghaus M., Slotta-Huspenina J., Weichert W., Knapp S., Feller S.M., Kuster B.
Pharmacoproteomic characterisation of human colon and rectal cancer.
Mol. Syst. Biol. 13:951-951(2017)


10、PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051
Yuan T.L., Amzallag A., Bagni R., Yi M., Afghani S., Burgan W., Fer N., Strathern L.A., Powell K., Smith B., Waters A.M., Drubin D.A., Thomson T., Liao R., Greninger P., Stein G.T., Murchie E., Cortez E., Egan R.K., Procter L., Bess M., Cheng K.T., Lee C.-S., Lee L.C., Fellmann C., Stephens R., Luo J., Lowe S.W., Benes C.H., McCormick F.
Differential effector engagement by oncogenic KRAS.
Cell Rep. 22:1889-1902(2018)


11、PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)


12、PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)


13、PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)


14、PubMed=32172478; DOI=10.1007/s12253-020-00805-3
Xu Y.-T., Zhang L., Wang Q.-L., Zheng M.-J.
Comparison of different colorectal cancer with liver metastases models using six colorectal cancer cell lines.
Pathol. Oncol. Res. 26:2177-2183(2020)


15、PubMed=34320349; DOI=10.1016/j.celrep.2021.109441
Jochems F., Thijssen B., De Conti G., Jansen R., Pogacar Z., Groot K., Wang L.-Q., Schepers A., Wang C., Jin H.-J., Beijersbergen R.L., Leite de Oliveira R., Wessels L.F.A., Bernards R.
The cancer SENESCopedia: a delineation of cancer cell senescence.
Cell Rep. 36:109441.1-109441.22(2021)


16、PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)


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